Clinical Characteristics of Japanese Patients Who Visited a COVID-19 Aftercare Clinic for Post-Acute Sequelae of COVID-19/Long COVID.
Clinical Characteristics of Japanese Patients Who Visited a COVID-19 Aftercare Clinic for Post-Acute Sequelae of COVID-19/Long COVID.
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DOI：
10.7759/cureus.18568
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Otsuka F
中科院分区：
文献类型：
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作者：
Otsuka Y;Tokumasu K;Nakano Y;Honda H;Sakurada Y;Sunada N;Omura D;Hasegawa K;Hagiya H;Obika M;Ueda K;Kataoka H;Otsuka F
2019冠状病毒病（COVID-19）急性期后的长期临床病程、预后以及症状和病症的最佳管理仍有待阐明。本研究的目的是澄清转诊至日本三级学术医院设立的COVID-19善后（CAC）诊所的患者的特征。方法本研究为描述性病例系列研究，纳入2021年2月15日至9月17日在CAC门诊就诊的所有患者。描述了患者的背景、主诉和COVID-19发病后的临床病程。结果共有87名日本患者（中位年龄40.0岁，四分位距26.5-53.0岁; 52.9%的女性）被转介到CAC诊所。COVID-19发病与到诊所就诊之间的中位间隔为79.0（IQR，52.5-112.0）天。转诊来源为医院（36名患者），诊所（47名患者），当地医疗中心（3例患者），以及其他最常见的主诉为全身乏力其次为嗅觉障碍（28.7%）、味觉障碍（26.4%）、脱发（18.4%）、头痛（17.2%）、呼吸困难（16.1%）和呼吸困难（13.1%）。呼吸道症状在疾病早期很常见，但在就诊时作为主诉并不常见。另一方面，神经、精神和肢体症状在COVID-19发病后一个月占主导地位。结论无论急性期的严重程度如何，到我们CAC诊所就诊的患者都有各种症状。熟练使用综合方法的普通医生最适合看到具有如此复杂症状的患者。
Introduction The long-term clinical course, prognosis, and optimal management of symptoms and conditions after the acute phase of coronavirus disease 2019 (COVID-19) remain to be elucidated. The purpose of this study was to clarify the characteristics of patients referred to a COVID-19 aftercare (CAC) clinic established at a tertiary academic hospital in Japan. Methods This study was a descriptive case series study. All patients who visited the CAC clinic between February 15 and September 17 in 2021 were included. Patients’ background, chief complaints, and clinical courses after the onset of COVID-19 were described. Results A total of 87 Japanese patients (median age, 40.0 years; interquartile range [IQR], 26.5-53.0 years; 52.9% women) were referred to the CAC clinic. The median interval between the onset of COVID-19 and the visit to the clinic was 79.0 (IQR, 52.5-112.0) days. Referral sources were hospitals (36 patients), clinics (47 patients), a local healthcare center (3 patients), and other (1 patient). The most common chief complaint was general fatigue (50.4%) followed by dysosmia (28.7%), dysgeusia (26.4%), hair loss (18.4%), headache (17.2%), dyspnea (16.1%), and dyssomnia (13.1%). Respiratory symptoms were common in the early stages of the disease but were less common as the chief complaints when visiting the clinic. On the other hand, neurological, psychiatric, and extremity symptoms were predominant one month after the onset of COVID-19. Conclusions Regardless of the severity in the acute phase, patients visiting our CAC clinic suffered from a variety of symptoms. General physicians skilled in using a comprehensive approach would be optimal to see patients with such complex symptoms.