Insulin/insulin-like growth factor signaling in C. elegans.
Insulin/insulin-like growth factor signaling in C. elegans.
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DOI：
10.1895/wormbook.1.164.1
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发表时间：
2013-12-26
期刊：
影响因子：
--
通讯作者：
Hu, Patrick J
中科院分区：
文献类型：
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作者：
Murphy, Coleen T;Hu, Patrick J
梭elegans胰岛素/IGF-1信号通路（IIS）将营养水平与代谢、生长、发育、寿命和行为联系起来。这一基本途径受与胰岛素/IGF-1跨膜受体（IGFR）直系同源物β 2结合的胰岛素样肽配体调节。IGFR-2/IGFR控制保守的磷酸肌醇3-激酶（PI 3 K）/Akt激酶级联的活性，最终调节FoxO转录因子，IGFR-16，其控制该途径的大部分功能。鉴于IIS途径的进化保守性，在C. elegans可能会揭示其在高等生物（包括人类）中的功能和调节。最初基于其在调节幼虫发育和衰老中的作用而确定，IIS还控制许多其他生物过程。本文就近年来有关C.秀丽隐翅虫
The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism, growth, development, longevity, and behavior. This fundamental pathway is regulated by insulin-like peptide ligands that bind to the insulin/IGF-1 transmembrane receptor (IGFR) ortholog DAF-2. DAF-2/IGFR controls the activity of a conserved phosphoinositide 3-kinase (PI3K)/Akt kinase cascade, culminating in the regulation of a FoxO transcription factor, DAF-16, that governs most of the functions of this pathway. In light of the evolutionary conservation of the IIS pathway, its study in C. elegans is likely to shed light on its functions and regulation in higher organisms, including humans. Originally identified based on its role in the regulation of larval development and aging, IIS also controls a host of other biological processes. Here we review what is currently known about the biological functions and the molecular components of C. elegans IIS.