Gender influence on jejunal migrating motor complex
Gender influence on jejunal migrating motor complex
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DOI：
10.1152/ajpgi.2001.280.2.g255
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发表时间：
2001-02-01
影响因子：
4.5
通讯作者：
Ulusoy, NB
中科院分区：
文献类型：
--
作者：
Aytug, N;Giral, A;Ulusoy, NB
性别和月经周期在小肠蠕动中的作用尚未明确阐明。使用装有五个固态压力传感器的鼻空肠导管记录了动态经期女性和年龄相当的男性在 24 小时内的空肠蠕动。所有女性均在月经周期的卵泡早期 (Early-F) 和黄体中期 (Lid-L) 阶段进行了两次研究，通过测定性腺类固醇和促性腺激素的血清水平进行验证。与男性相比，两个月经周期阶段的III期传播速度较慢，收缩幅度较高，这些参数与中期L期血清雌激素水平相关。在F早期，睡眠期间的迁移运动复合体（MMC）周期持续时间与其他组相比较长，并且与雌激素浓度呈正相关，而在L中期，睡眠期间的MMC周期持续时间与血清黄体酮水平呈负相关。在所有组中，与清醒状态相比，睡眠期间 III 期收缩的频率较低，并且从压力峰值到峰值测量的收缩间期较长。餐后运动在任何检查参数中均未显示出性别差异。结果表明，经期女性和男性的大多数运动模式相似，而 MMC 的某些方面（最明显的传播速度和 III 期收缩幅度）不同。我们还记录了女性和男性第三期宫缩频率的昼夜节律变化。
The role of gender and the menstrual cycle in small bowel motility has not been clearly elucidated. Jejunal motility was recorded with a nasojejunal catheter incorporating five solid-state pressure transducers in ambulatory menstruating women and men of comparable age over 24 h. All women were studied twice, in the early follicular (early-F) and midluteal (mid-L) phases of the menstrual cycle, verified by determining serum levels of gonadal steroids and gonadotropins. The propagation velocity of phase III was slow and the contraction amplitude was high in both menstrual cycle phases compared with men, and these parameters were correlated with serum estrogen levels in the mid-L phase. In the early-F phase, migrating motor complex (MMC) cycle duration during sleep was long compared with other groups and positively correlated with estrogen concentrations, whereas in the mid-L phase MMC cycle duration during sleep was negatively correlated with serum progesterone levels. In all groups, the frequency of phase III contractions was low and the intercontractile interval measured from pressure peak to peak was long during sleep compared with the awake state. Postprandial motility did not display gender difference in any parameter examined. The results demonstrate that the majority of patterns of motility are similar in menstruating women and men, whereas certain aspects of the MMC, most conspicuously propagation velocity and phase III contraction amplitude, differ. We have also documented circadian variation of phase III contraction frequency in both women and men.