Persistent ectopic expression of Drosophila homeotic genes resulting from maternal deficiency of the extra sex combs gene product.
Persistent ectopic expression of Drosophila homeotic genes resulting from maternal deficiency of the extra sex combs gene product.
复制标题
由于母体缺乏额外的性梳基因产物而导致果蝇同源基因的持续异位表达。
DOI：
10.1016/0012-1606(90)90364-o
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发表时间：
1990
影响因子：
2.7
通讯作者：
Brower,DL
中科院分区：
文献类型：
--
作者：
Glicksman,MA;Brower,DL
像Polycomb组的其他成员一样，额外性梳基因（esc）是主要同源异型基因复合体中正确抑制位点所必需的。我们发现，在胚带缩短过程中，缺乏母体和合子c+功能的胚胎表现出短暂的、普遍的超双胸（Ubx）和触角足（Antp）基因的去抑制，但性梳减少（Scr）的表达在表皮中几乎正常，而在中枢神经系统（CNS）中缺乏。此外，母体esc-但接受两个父系esc+拷贝的胚胎通常以三个同源异型基因的异位表达为特征，特别是中枢神经系统的Ubx和Antpin。来自这些父亲拯救的胚胎的想象盘可能显示不连续的Ubx和Scrin表达的不适当位置。因此，在胚胎发育早期的短时期内缺乏esc+功能会导致确定状态的可遗传变化，即使在遗传野生型动物中也是如此。在这些异位补丁，同源异型基因的表达可能受到光盘的位置字段和同源异型基因之间的交叉调节相互作用。
Like other members of thePolycombgroup, theextra sex combsgene (esc) is required for the correct repression of loci in the major homeotic gene complexes. We show here that embryos lacking both maternal and zygoticesc+function display transient, general derepression of both theUltrabithorax(Ubx) andAntennapedia(Antp) genes during germ band shortening, butSex combs reduced(Scr) expression is almost normal in the epidermis and lacking in the central nervous system (CNS). In addition, embryos that are maternallyesc−but receive two paternal copies ofesc+often are characterized by ectopic expression of the three homeotic genes, especiallyUbxandAntpin the CNS. Imaginal discs from these paternally rescued embryos may show discrete patches of expression ofUbxandScrin inappropriate locations. Thus, lack ofesc+function during a brief period in early embryogenesis results in a heritable change in determined state, even in a genetically wild type animal. Within these ectopic patches, homeotic gene expression may be regulated by the disc positional fields and by cross-regulatory interactions between homeotic genes.