Periodontal disease and hypertriglyceridemia in Japanese subjects: potential association with enhanced lipolysis
Periodontal disease and hypertriglyceridemia in Japanese subjects: potential association with enhanced lipolysis
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DOI：
10.1016/j.metabol.2010.07.034
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发表时间：
2011-06-01
影响因子：
9.8
通讯作者：
Nishimura, Fusanori
中科院分区：
文献类型：
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作者：
Nakarai, Hideo;Yamashita, Akiko;Nishimura, Fusanori
虽然牙周病可能与动脉粥样硬化的风险增加有关，但该疾病导致动脉粥样硬化的机制仍然未知。牙周病中导致动脉粥样硬化的候选者包括低度炎症，如C反应蛋白（CRP）和胰岛素抵抗。先前的研究表明，牙周治疗导致CRP和胰岛素抵抗的改善，表明牙周病与低度炎症或胰岛素抵抗之间的关系。另一方面，我们以前证明，血清甘油三酯（TG）本身是独立相关的CRP或胰岛素抵抗的日本人群与体重指数（BMI）为21.5至27.0（中等BMI）。然而，据我们所知，牙周病和血清甘油三酯之间的关系并不完全清楚。本研究的第一个目的是调查是否牙周病与血清甘油三酯在日本受试者与中等体重指数。如果是这样的话，本研究的另一个目的是确定哪些机制是负责牙周病和血清甘油三酯之间的关联，在这些科目。我们在大垣代谢综合征医学检查中进行了牙周检查。162名40至74岁的参与者（56名男性和106名女性;平均年龄为66.43 +/- 6.25岁）参加了这项研究。除体格检查外，所有参与者均接受口腔全景X线片。还计算了平均骨评分。牙周骨破坏随年龄增长而增加（r = 0.227，P <0.004，斯皮尔曼相关系数）。牙周骨破坏也与血清TG水平相关（r = 0.299，P = .000）。这种关联在中等BMI的受试者中更为明显（r = 0.332，P <0.001）。在中等BMI的受试者中，TG与BMI或废物情况无关。此外，在中等BMI组中，TG与年龄本身无关。然后，我们研究了脂肪细胞和巨噬细胞共培养物中内毒素的脂解活性。低剂量的脂多糖剂量依赖性地增加脂肪分解活性的共培养物，这种活性被中和的抗肿瘤坏死因子a中和抗体。这些结果表明，牙周感染，特别是细菌性内毒素血症，与增强脂解和随后上调循环TG在日本与中等BMI。(C)2011 Elsevier Inc. All rights reserved.
Although periodontal disease may be associated with increased risk for atherosclerosis, the mechanism by which the disease causes atherosclerosis is still unknown. The candidates contributing to atherosclerosis in periodontal disease include low-grade inflammation such as C-reactive protein (CRP) and insulin resistance. A previous study demonstrated that periodontal therapy leads to an improvement in CRP as well as insulin resistance, indicating the relationship between periodontal disease and low-grade inflammation or insulin resistance. On the other hand, we previously demonstrated that serum triglyceride (TG) per se is independently associated with CRP or insulin resistance in Japanese populations with a body mass index (BMI) of 21.5 to 27.0 (midrange BMI). To the best of our knowledge, however, the relationship between periodontal disease and serum TG is not fully clarified. The first aim of the present study is to investigate whether periodontal disease is associated with serum TG in Japanese subjects with midrange BMI. If so, another aim of the study is to determine which mechanism is responsible for the association between periodontal disease and serum TG in these subjects. We have performed a periodontal examination in the Ogaki metabolic syndrome medical examination. One hundred sixty-two participants from 40 to 74 years old (56 men and 106 women; mean age, 66.43 +/- 6.25 years) were enrolled in the study. Besides medical examination, oral panoramic radiograph was taken for all participants. Average bone score was also calculated. Periodontal bone destruction increased according to the age of the participants (r = 0.227, P < .004, Spearman correlation coefficient). Periodontal bone destruction was also associated with serum TG levels (r = 0.299, P = .000). This association was more evident in subjects with midrange BMI (r = 0.332, P < .001). In subjects with midrange BMI, TG was not correlated with BMI or waste circumstances. Furthermore, TG was not associated with age itself in the midrange BMI group. We then investigated the lipolytic activity of endotoxin in cocultures of adipocytes and macrophages. Low-dose lipopolysaccharide dose-dependently increased lipolytic activity in cocultures, and this activity was neutralized by anti-tumor necrosis factor a neutralizing antibodies. These results suggest that periodontal infection, especially bacterial endotoxinemia, is associated with enhanced lipolysis and subsequent up-regulation of circulating TG in Japanese with midrange BMI. (C) 2011 Elsevier Inc. All rights reserved.