Design of Biomolecules for Nanoengineered Biomaterials for Regenerative Medicine
Design of Biomolecules for Nanoengineered Biomaterials for Regenerative Medicine
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DOI：
10.1007/978-1-61779-388-2_3
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发表时间：
2012-01-01
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影响因子：
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通讯作者：
Stupp, Samuel I.
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文献类型：
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作者：
Mata, Alvaro;Palmer, Liam;Stupp, Samuel I.
开发高功能有机材料的一个重要目标是设计能够在不同长度尺度上重复显示化学信号的自组装分子。在生物医学领域，生物分子是非常有吸引力的候选者，可以作为下一代生物材料的生物活性构建块。西北大学Stapp实验室开发的肽两亲体（PAs）产生了一种高度通用的自组装代码，用于创建定义良好的生物活性纳米纤维，这种纳米纤维已被证明在体外和体内对信号细胞非常有效。在这里，我们描述了合成和组装成功能纳米结构的PA分子的基本步骤。
An important goal in the development of highly functional organic materials is to design self-assembling molecules that can reproducibly display chemical signals across length scales. Within the biomedical field, biomolecules are highly attractive candidates to serve as bioactive building blocks for the next generation of biomaterials. The peptide amphiphiles (PAs) developed by the Stapp Laboratory at Northwestern University generated a highly versatile self-assembly code to create well-defined bioactive nanofibers that have been proven to be very effective at signaling cells in vitro and in vivo. Here, we describe the basic steps necessary for synthesis and assembly of PA molecules into functional nanostructures.