An operation under general anesthesia as a risk factor for age-related cognitive decline: Results from a large cross-sectional population study
An operation under general anesthesia as a risk factor for age-related cognitive decline: Results from a large cross-sectional population study
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DOI：
10.1111/j.1532-5415.1998.tb04542.x
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发表时间：
1998-10-01
影响因子：
6.3
通讯作者：
Jolles, J
中科院分区：
文献类型：
--
作者：
Dijkstra, JB;Van Boxtel, MPJ;Jolles, J
目的：评估因素“全麻下手术”作为一个可能的危险因素与年龄相关的认知能力下降。设计：一个回顾性的，以人口为基础的，横断面研究。设置：马斯特里赫特老龄化研究（MAAS），马斯特里赫特，荷兰。参与者：1257名正常健康受试者，年龄24至86岁。在1257名健康受试者中，946名受试者似乎至少经历过一次全身麻醉下的手术。测量：对全身麻醉下的手术史、手术次数、麻醉持续时间、认知能力、主观健康和主观记忆进行测量。全身麻醉手术史，手术次数，麻醉的总持续时间对主观健康相关的抱怨数量有显著影响，但不能预测认知能力或记忆抱怨。有全身麻醉手术史的受试者比从未接受过全身麻醉手术的受试者感觉更不健康。没有与年龄的相互作用被发现。结论：本研究发现没有支持的概念，即在全身麻醉下的手术史是一个决定因素或风险因素，加速与年龄相关的认知能力下降。
OBJECTIVE: To evaluate the factor 'operation under general anesthesia' as a possible risk factor for age-related cognitive decline.DESIGN: A retrospective, population-based, cross-sectional study.SETTING: Maastricht Aging Study (MAAS), Maastricht, The Netherlands.PARTICIPANTS: 1257 normal healthy subjects aged 24 to 86 years. Of the 1257 healthy subjects, 946 subjects appeared to have undergone at least one operation under general anesthesia.MEASUREMENTS: The history of an operation under general anesthesia, number of operations, duration of anesthesia, cognitive performance, subjective health, and subjective memory were measured.RESULTS: The history of an operation under general anesthesia, the number of operations, and the total duration of anesthesia significantly contributed to the number of subjective health-related complaints but did not predict cognitive performance or memory complaints. Subjects with a history of an operation under general anesthesia felt less healthy than subjects who had never undergone an operation under general anesthesia. No interactions with age were found.CONCLUSION: The present study found no support for the notion that a history of an operation under general anesthesia is a determinant or risk factor for accelerated age-related cognitive decline.