Reactivation of herpes simplex virus type 1 in patients with Bell's palsy
Reactivation of herpes simplex virus type 1 in patients with Bell's palsy
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DOI：
10.1002/(sici)1096-9071(199803)54:3
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发表时间：
1998-03
影响因子：
12.7
通讯作者：
Y. Furuta;S. Fukuda;E. Chida;T. Takasu;F. Ohtani;Y. Inuyama;K. Nagashima
中科院分区：
文献类型：
--
作者：
Y. Furuta;S. Fukuda;E. Chida;T. Takasu;F. Ohtani;Y. Inuyama;K. Nagashima
单纯疱疹病毒1型（HSV-1）的再活化与特发性周围性面神经麻痹（贝尔麻痹）的发病机制有关。本研究使用聚合酶链反应（PCR）分析贝尔麻痹患者唾液中是否存在脱落的HSV-1。该研究涉及47名贝尔麻痹患者，24名Ramsay Hunt综合征患者和16名健康HSV血清阳性志愿者。在HSV-血清阴性患者的唾液样本中未检出HSV-1 DNA。Bell麻痹患者的HSV-1感染率（50%）显著高于健康志愿者（19%，p<0.05）。当在麻痹发作后7天内检测唾液样本时，贝尔麻痹患者的HSV-1脱落率（40%）显著高于拉姆齐亨特综合征患者（7%，p<0.05）。此外，当在疾病的急性期检测到HSV-1时，HSV-1通常在贝尔麻痹发作后第二周检测不到。这些发现强烈表明，HSV-1的再激活参与了贝尔麻痹的发病机制，并表明PCR是贝尔麻痹患者HSV-1再激活的早期诊断的有用工具。医学病毒学杂志54：162-166，1998.© 1998 Wiley利斯公司
Reactivation of herpes simplex virus type 1 (HSV‐1) has been implicated in the pathogenesis of idiopathic peripheral facial palsy (Bell's palsy). The present study used the polymerase chain reaction (PCR) to analyze the saliva of patients with Bell's palsy for the presence of shed HSV‐1. The study involved 47 patients with Bell's palsy, 24 patients with Ramsay Hunt syndrome, and 16 healthy HSV‐seropositive volunteers. HSV‐1 DNA was not detected in the saliva samples from HSV‐seronegative patients. The prevalence of shed HSV‐1 in patients with Bell's palsy (50%) was significantly higher than that in healthy volunteers (19%, p<0.05). When saliva samples were tested within 7 days after the onset of palsy, the prevalence of shed HSV‐1 in patients with Bell's palsy (40%) was significantly higher than that in patients with Ramsay Hunt syndrome (7%, p<0.05). Furthermore, HSV‐1 usually became undetectable by the second week after the onset of Bell's palsy when HSV‐1 was detected during the acute phase of the disease. These findings strongly suggest that reactivation of HSV‐1 is involved in the pathogenesis Bell's palsy, and indicate that PCR is a useful tool for early diagnosis of HSV‐1 reactivation in patients with Bell's palsy. J. Med. Virol. 54:162–166, 1998. © 1998 Wiley‐Liss, Inc.