Abnormal degree centrality in lifelong premature ejaculation patients: an fMRI study
Abnormal degree centrality in lifelong premature ejaculation patients: an fMRI study
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终生早泄患者的异常程度中心性：一项功能磁共振成像研究
DOI：
10.1007/s11682-020-00340-4
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发表时间：
2020-08-06
影响因子：
3.2
通讯作者：
Liu, Peng
中科院分区：
文献类型：
--
作者：
Gao, Ming;Feng, Nana;Liu, Peng
终生性早泄（PE）是最常见的男性性功能障碍之一。终身体育的可能神经机制尚不清楚。本研究旨在探讨终身体育患者脑功能网络的异常特点，并探讨其与临床症状的关系。收集2016年以来45例终身PE患者和37例健康对照者（HC）的功能磁共振成像（fMRI）数据和临床症状，包括疾病和性生活史、秒表测量的阴道内射精潜伏期时间等量表。应用程度中心性（DC）方法区分两组之间的脑功能改变（p< 0.05，错误发现率校正）。然后进行相关性分析，以检查影像学表现与临床症状之间的关系（p< 0.05，Bonferroni校正）。结果显示，与HCs相比，终身PE患者内侧前额叶皮层（mPFC）、楔前叶和初级躯体感觉皮层（SI）的DC值增加，而颞叶和眶额皮层的DC值降低。在控制焦虑和抑郁水平后，两组mPFC差异无统计学意义，SI的DC值与早泄诊断工具（PEDT）评分呈正相关。目前的研究结果表明，终身PE患者改变了DC在大脑区域参与感觉，动机和抑制控制处理。本研究有助于加深对终身体育的认识，为终身体育的进一步研究提供新的视角。
Lifelong premature ejaculation (PE) is one of the most prevalent male sexual dysfunctions. It is still not well known about the possible neural mechanisms of lifelong PE. This study tried to investigate the abnormal characteristics of brain functional networks of lifelong PE and to assess relationships of PE-related functional abnormalities with clinical symptoms. Functional magnetic resonance imaging (fMRI) data and clinical symptoms were collected from 45 lifelong PE patients and 37 healthy controls (HCs) since 2016, including disease and sexual life history, intravaginal ejaculatory latency time measured by stopwatch and other scales. The degree centrality (DC) approach were applied to distinguish altered brain functions between the two groups (p< 0.05, false discovery rate corrected). Correlation analysis was then performed to examine relationships between the imaging findings and clinical symptoms (p< 0.05, Bonferroni corrected). Results showed that compared with HCs, lifelong PE patients had increased DC value in the medial prefrontal cortex (mPFC), precuneus and primary somatosensory cortex (SI) as well as decreased DC value in the insula and orbitofrontal cortex. After controlling for anxiety and depression levels, the significant difference in the mPFC was not found. The DC value in the SI positively correlated with premature ejaculation diagnostic tool (PEDT) score in the patients. The present findings indicate that lifelong PE patients have altered DC in brain regions involved in sensation, motivation and inhibitory control processing. Our study may improve our understanding and provide a new sight into the further research of lifelong PE.