Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases.
Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases.
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DOI：
10.1111/j.1600-065x.2011.01024.x
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发表时间：
2011-07
影响因子：
8.7
通讯作者：
Oettgen HC
中科院分区：
文献类型：
--
作者：
Burton OT;Oettgen HC
免疫球蛋白E （IgE）抗体一直被认为是过敏反应的抗原特异性触发因子。本文简要介绍了IgE在即时超敏反应中的作用，重点介绍了我们和其他研究的新证据，IgE在对寄生虫的保护性免疫中发挥重要作用，并对其自身受体FcεRI和CD23的表达产生调节作用，并控制肥大细胞的稳态。我们概述了IgE抗体对食物过敏病理的多方面影响，并推测了IgE阻断的潜在作用机制。
Immunoglobulin E (IgE) antibodies have long been recognized as the antigen-specific triggers of allergic reactions. This review briefly introduces the established functions of IgE in immediate hypersensitivity and then focuses on emerging evidencefrom our own investigations as well as those of others that IgE plays important roles in protective immunity against parasites and exerts regulatory influences in the expression of its own receptors, FcεRI and CD23, as well as controlling mast cell homeostasis. We provide an overview of the multifaceted ways in which IgE antibodies contribute to the pathology of food allergy and speculate regarding potential mechanisms of action of IgE blockade.