Bone Immune Response to Materials, Part II: Copper and Polyetheretherketone (PEEK) Compared to Titanium at 10 and 28 Days in Rabbit Tibia
Bone Immune Response to Materials, Part II: Copper and Polyetheretherketone (PEEK) Compared to Titanium at 10 and 28 Days in Rabbit Tibia
复制标题
DOI：
10.3390/jcm8060814
复制
发表时间：
2019-06
影响因子：
3.9
通讯作者：
Ricardo Trindade;T. Albrektsson;S. Galli;Zdenka Prgomet;P. Tengvall;A. Wennerberg
中科院分区：
文献类型：
--
作者：
Ricardo Trindade;T. Albrektsson;S. Galli;Zdenka Prgomet;P. Tengvall;A. Wennerberg
骨整合可能是免疫驱动的骨对钛等材料反应的结果。骨整合使得口腔种植体锚在颌骨组织中的临床应用成为可能。然而，骨锚定背后的机制尚未完全理解，并且已报告了较长时间内的并发症。本研究旨在探索铜（Cu）和聚醚醚酮（PEEK）材料之间可能存在的差异，这些材料不会与骨结合，而与骨结合的cp钛作为对照。将植入物放置在兔胫骨中，并在随访的第10天和第28天评价选定的免疫标记物。Cu和PEEK在两个时间点的免疫活化均高于cp钛。Cu由于随时间推移维持的促炎环境而表现出远距离成骨，PEEK由于其表面上免疫学定义的优先脂肪组织形成而未能骨整合。这里呈现的结果提示了两种不同的失败的骨整合机制的描述，这两种机制都与免疫系统相关。
Osseointegration is likely the result of an immunologically driven bone reaction to materials such as titanium. Osseointegration has resulted in the clinical possibility to anchor oral implants in jaw bone tissue. However, the mechanisms behind bony anchorage are not fully understood and complications over a longer period of time have been reported. The current study aims at exploring possible differences between copper (Cu) and polyetheretherketone (PEEK) materials that do not osseointegrate, with osseointegrating cp titanium as control. The implants were placed in rabbit tibia and selected immune markers were evaluated at 10 and 28 days of follow-up. Cu and PEEK demonstrated at both time points a higher immune activation than cp titanium. Cu demonstrated distance osteogenesis due to a maintained proinflammatory environment over time, and PEEK failed to osseointegrate due to an immunologically defined preferential adipose tissue formation on its surface. The here presented results suggest the description of two different mechanisms for failed osseointegration, both of which are correlated to the immune system.