Higher lipoprotein-associated phospholipase A2 levels are associated with coronary atherosclerosis documented by coronary angiography
Higher lipoprotein-associated phospholipase A2 levels are associated with coronary atherosclerosis documented by coronary angiography
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DOI：
10.1258/acb.2012.011252
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发表时间：
2012-11-01
影响因子：
2.2
通讯作者：
Daida, Hiroyuki
中科院分区：
文献类型：
--
作者：
Dohi, Tomotaka;Miyauchi, Katsumi;Daida, Hiroyuki
背景：脂蛋白相关磷脂酶A2（Lp-PLA 2）被认为是心血管疾病的炎症标志物。本研究调查了日本冠心病患者Lp-PLA 2与其他重要生物标志物之间的关系。方法：我们检测了141例连续患者的Lp-PLA 2水平（年龄62.6 ± 3.8岁;男性69.2%），有冠状动脉疾病的血管造影证据（急性冠脉综合征[ACS]; n = 38），稳定型心绞痛（SAP; n = 72）或冠状动脉造影正常（NCA; n = 31）。Lp-PLA 2水平与低密度脂蛋白胆固醇显著相关同型半胱氨酸（r = 0.528）、对氧磷酶（r = 0.401），P均< 0.01。冠状动脉粥样硬化（ACS）和SAP患者的Lp-PLA 2水平显著高于NCA患者（P < 0.05）。ACS患者超敏C反应蛋白水平显著高于SAP和NCA患者（P均< 0.05）。多因素Logistic回归分析显示，高水平的Lp-PLA 2与冠状动脉粥样硬化独立相关（优势比：1.058，95%可信区间：1.012-1.121; P = 0.001）。因此，Lp-PLA 2是日本患者冠状动脉粥样硬化的新生物标志物。《临床生物化学年鉴》2012; 49：527-533。DOI：10.1258/acb.2012.011252
Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been proposed as an inflammatory marker of cardiovascular disease. The present study investigates associations between Lp-PLA2 and other important biomarkers in Japanese patients with coronary artery disease.Methods: We measured Lp-PLA2 levels in 141 consecutive patients (age 62.6 +/- 3.8 years; men 69.2%) with angiographic evidence of coronary artery disease (acute coronary syndrome [ACS]; n = 38), stable angina pectoris (SAP; n = 72) or with angiographically normal coronary arteries (NCA; n = 31).Results: Levels of Lp-PLA2 significantly correlated with low-density lipoprotein-cholesterol (r = 0.302), homocysteine (r = 0.528) and paraoxonase (r = 0.401) in all patients (all P < 0.01). Levels of Lp-PLA2 were significantly higher in patients with coronary atherosclerosis (ACS and SAP) than with NCA (P < 0.05). Levels of highly sensitive C-reactive protein were significantly higher in patients with ACS than with SAP and NCA (both P < 0.05). Multivariate logistic regression analyses revealed that higher Lp-PLA2 levels were independently associated with coronary atherosclerosis (odds ratio: 1.058; 95% confidence interval: 1.012-1.121; P = 0.001).Conclusions: Higher Lp-PLA2 levels are associated with coronary atherosclerosis independently of traditional coronary risk factors. Thus, Lp-PLA2 is a novel biomarker of coronary atherosclerosis in Japanese patients. Ann Clin Biochem 2012; 49: 527-533. DOI: 10.1258/acb.2012.011252