Phenotypic associations of tau and ApoE in Parkinson's disease
Phenotypic associations of tau and ApoE in Parkinson's disease
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DOI：
10.1016/j.neulet.2006.12.008
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发表时间：
2007-03-06
影响因子：
2.5
通讯作者：
Mash, Deborah C.
中科院分区：
文献类型：
--
作者：
Papapetropoulos, Spiridon;Farrer, Matthew J.;Mash, Deborah C.
帕金森病 (PD)、痴呆和运动性 tau 病的临床、病理和分子特征的重叠促使人们进行关联研究，寻找可能诱发或改变此类疾病的常见遗传风险因素。为了探索可能的表型影响，我们在具有临床和病理特征的 PD 患者和老年对照受试者队列中研究了与阿尔茨海默病 (AD)、进行性核上性麻痹 (PSP) 和 PD 相关的常见 tau 和 ApoE 基因多态性。我们的结果揭示了 PD 相关幻觉与 HIM 基因型之间的新关联。我们还报告了 PDD 与 ApoE epsilon 4 等位基因的存在之间的关联。根据特定表型特征的存在更好地确定 PD 患者亚群可能会提高关联研究的准确性。 (c) 2006 年，爱思唯尔爱尔兰有限公司出版。
Overlaps in clinical, pathological and molecular features of Parkinson's disease (PD), dementing and motor tauopathies have prompted association studies in search of common genetic risk factors that may predispose or modify this spectrum of disorders. To explore possible phenotypic implications, we studied common tau and ApoE gene polymorphisms, associated with Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and PD, in a clinically and pathologically characterized cohort of PD patients and aged control subjects. Our results reveal a novel association between PD-related hallucinations and HIM genotype. We also report an association between PDD and the presence of the ApoE epsilon 4 allele. Better determination of subsets of PD patients based upon the presence of specific phenotypic features may improve the accuracy of association studies. (c) 2006 Published by Elsevier Ireland Ltd.