STUDIES ON INFECTION WITH BACILLUS-ANTHRACIS .1. A HISTOPATHOLOGICAL STUDY OF SKIN LESIONS PRODUCED BY B-ANTHRACIS IN SUSCEPTIBLE AND RESISTANT ANIMAL SPECIES
STUDIES ON INFECTION WITH BACILLUS-ANTHRACIS .1. A HISTOPATHOLOGICAL STUDY OF SKIN LESIONS PRODUCED BY B-ANTHRACIS IN SUSCEPTIBLE AND RESISTANT ANIMAL SPECIES
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DOI：
10.1093/infdis/80.1.1
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发表时间：
1947-01-01
影响因子：
6.4
通讯作者：
WATSON, DW
中科院分区：
文献类型：
--
作者：
CROMARTIE, WJ;BLOOM, WL;WATSON, DW
敏感和相对耐药菌株皮肤和皮下组织病变的组织病理学研究。在引入B的孢子后动物的死亡率。炭疽进行了。2-4小时。注射后，B的萌发和增殖。炭疽病在所有菌种的细胞间液中进行。在此期间，微生物被包囊，其染色特性表明其活力。在易感动物中，增殖似乎继续进行，直到死亡终止该过程，并且绝大多数微生物保留了其荚膜和原始染色质量。在耐药动物中，4小时后的杆菌。失去了它们的包膜，表现出死亡和崩解的染色特征，并逐渐从病变中消失。该过程与许多白细胞浸润该区域有关，但吞噬作用不是该过程的显著特征。微生物倾向于聚集在病灶中;组织变化延伸至病灶周围一定距离，并存在于相邻肌肉组织中。从这些观察中得出以下结论：抗性和敏感种的细胞外组织液。最初支持B萌发和增殖。炭疽病约4小时。注射后，这种流体的质量在相对抗性物种中以导致荚膜损失和杆菌崩解的方式改变。白细胞是在耐药动物中引起这种效应的物质的可能来源之一。感染发病机制的种属差异似乎与影响包膜形成的因素有关。组织变化的特征表明，它们可能是由生物体释放的可扩散物质产生的。
A histopathological study of lesions produced in the skin and subcutaneous tissues of susceptible and relatively resistant spp. of animals following the introduction of spores of B. anthracis was carried out. For 2-4 hrs. after injn., germination and proliferation of B. anthracis proceeded in the intercellular fluids of all spp. During this period the organisms were encapsulated and their staining properties indicated their viability. Proliferation appeared to continue in the susceptible animals until death terminated the process and the large majority of organisms retained their capsules and original staining qualities. In the resistant animals, the bacilli after 4 hrs. lost their capsules, exhibited staining characteristics of death and disintegration, and gradually disappeared from the lesions. This process was associated with infiltration of the area by many leucocytes, but phagocytosis was not a prominent feature of the process. The organisms tended to collect in foci; tissue changes extended for some distance around the foci and were present in the adjacent muscle tissue. From these observations the following conclusions were drawn: the extracellular tissue fluids of resistant and susceptible spp. initially support germination and proliferation of B. anthracis. Approx. 4 hrs. after injn., the quality of this fluid is changed in the relatively resistant species in such a manner as to lead to loss of capsule and disintegration of bacilli. Leucocytes are among the possible sources of the substance responsible for this effect in resistant animals. Species differences in the pathogenesis of the infection appear to be related to factors which affect capsule formation. The character of the tissue changes suggests that they may be produced by a diffusible substance, liberated by the organism.