Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly.
Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly.
复制标题
DOI：
10.1016/j.devcel.2017.01.001
复制
发表时间：
2017-02-06
影响因子：
11.8
通讯作者：
Martin P
中科院分区：
文献类型：
--
作者：
Wood W;Martin P
巨噬细胞是一种多功能的先天免疫细胞，它为体内的所有组织提供种子，在整个发育过程中以及在成人组织中扮演着不同的角色，无论是在健康还是疾病中。它们复杂的发育起源和许多功能正在哺乳动物组织中破译，但活体成像的机会和果蝇的遗传易感性为我们提供了补充的见解，让人们了解这些迷人的细胞如何整合多种指导线索来完成许多任务，并迁移到遥远的位置，要么指导发育模式，要么引发炎症反应。伍德和马丁讨论了小鼠和果蝇巨噬细胞在发育、吞噬、模式和免疫反应以及疾病状态方面的相似之处。他们讨论了活体成像和苍蝇遗传学带来的进步，以及如何将昆虫和哺乳动物系统的洞察力结合起来。
Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but opportunities for live imaging and the genetic tractability of Drosophila are offering complementary insights into how these fascinating cells integrate a multitude of guidance cues to fulfill their many tasks and migrate to distant sites to either direct developmental patterning or raise an inflammatory response. Wood and Martin discuss the similarities between mouse and Drosophila macrophages in the contexts of development, phagocytosis, patterning and immune response, and disease states. They discuss the advances allowed by live imaging and fly genetics, and how insights from both insect and mammalian systems can be combined.