The aging of Wolff's "Law": Ontogeny and responses to mechanical loading in cortical bone
The aging of Wolff's "Law": Ontogeny and responses to mechanical loading in cortical bone
复制标题
DOI：
10.1002/ajpa.20155
复制
发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Lieberman, Daniel E.
中科院分区：
文献类型：
--
作者：
Pearson, Osbjorn M.;Lieberman, Daniel E.
骨骼在一生中生长和重塑以适应其机械环境的前提通常被称为沃尔夫定律。然而，沃尔夫定律并不总是正确的，事实上，它包括各种不同的过程，最好分别考虑。在这里，我们审查的分子和生理机制，骨的感觉，转导，并响应机械负荷，和老化过程中的影响之间的关系（如果有的话）皮质骨的形式和机械功能。实验和比较证据表明，皮质骨主要对性成熟前的应变有反应，无论是在新骨生长（建模）的速度，以及周转率（哈佛重塑）。然而，在不同的骨骼部位，建模和哈弗氏重建的速率差异很大。此外，在长骨骨干中的载荷方向与其横截面几何形状之间没有简单的关系。结合起来，这些数据警告不进行测试，以推断成人活动模式的骨骼特征，如横截面的几何形状，皮质骨密度，肌肉骨骼应力标记的形式功能关系的适应性观点的假设。从人类骨骼的形状推断功能的努力应该基于经过实验测试和验证的生物力学和发育模型。
The premise that bones grow and remodel throughout life to adapt to their mechanical enironment is often called Wolffs law. Wolffs law, however, is not always true, and in fact comprises a variety of different processes that are best considered separately. Here we review the molecular and physiological mechanisms by which bone senses, transduces, and responds to mechanical loads, and the effects of aging processes on the relationship (if any) between cortical bone form and mechanical function. Experimental and comparative evidence suggests that cortical bone is primarily responsive to strain prior to sexual maturity, both in terms of the rate of new bone growth (modeling) as well as rates of turnover (Haversian remodeling). Rates of modeling and Haversian remodeling, however, vary greatly at different skeletal sites. In addition, there is no simple relationship between the orientation of loads in long bone diaphyses and their cross-sectional geometry. In combination, these data caution against assuming without testing adaptationist views about form-function relationships in order to infer adult activity patterns from skeletal features such as cross-sectional geometry, cortical bones density, and musculoskeletal stress markers. Efforts to infer function from shape in the human skeleton should be based on biomechanical and developmental models that are experimentally tested and validated.