Population-based assessment of intensive care unit-acquired bloodstream infections in adults: Incidence, risk factors, and associated mortality rate
Population-based assessment of intensive care unit-acquired bloodstream infections in adults: Incidence, risk factors, and associated mortality rate
复制标题
DOI：
10.1097/00003246-200211000-00010
复制
发表时间：
2002-11-01
影响因子：
8.8
通讯作者：
Doig, CJ
中科院分区：
文献类型：
--
作者：
Laupland, KB;Zygun, DA;Doig, CJ
Objective.医院内血流感染已被广泛研究，但相对较少的研究专门评估重症监护病房获得性血流感染的流行病学。本研究的目的是确定重症监护病房获得性血流感染的发病率、危险因素、微生物学和临床结局。基于人口的前瞻性队列。多学科重症监护病房患者：1999年5月1日至2000年4月30日，所有卡尔加里卫生区（人口930，000）成人患者入住多学科重症监护病房（48小时）。血液样本分析。测量和结果。在1,017名患者中有1,158次入院事件; 37%涉及女性，平均sD年龄和急性生理学和慢性健康评估11评分分别为59.6 +/- 18.7岁和23.4 +/- 7.7。51例患者发生重症监护病房获得性血流感染（首次阳性血培养大于或等于重症监护病房入院后48小时），发生率为4.4%，发病密度为5.2/1000重症监护病房日。年龄较轻（校正比值比，0.98; 95%置信区间，0.96-1.00，p = 0.01），重症监护室住院时间较长（校正比值比，4.74; 95% CI，3.26-6.90，p
Objective. Nosocomial bloodstream infections have been extensively investigated, but relatively few studies have specifically evaluated the epidemiology of intensive care unit-acquired bloodstream infections. The study objective was to define the incidence, risk factors, microbiology, and clinical outcomes of intensive care unit-acquired bloodstream infections.Design. Population-based prospective cohort.Setting. Multidisciplinary intensive care units.Patients: All Calgary Health Region (population 930,000) adult patients admitted to multidisciplinary intensive care units ( :48 hrs) from May 1, 1999, to April 30, 2000.Interventions. Blood sample analysis.Measurements and Results. There were 1,158 admission episodes in 1,017 patents; 37% involved females, and mean sD age and Acute Physiology and Chronic Health Evaluation 11 scores were 59.6 +/- 18.7 yrs and 23.4 +/- 7.7, respectively. Fifty-one patients developed intensive care unit-acquired bloodstream infections (first positive blood culture greater than or equal to48 hrs after intensive care unit admission) for an incidence of 4.4% and an incidence density of 5.2 per 1000 intensive care unit days. Younger age (adjusted odds ratio, 0.98; 95% confidence interval, 0.96-1.00, p =.01), longer intensive care unit length of stay (adjusted odds ratio, 4.74; 95% Cl, 3.26-6.90, p