Reexpression of normal stem cells in erythroleukemia during remission
Reexpression of normal stem cells in erythroleukemia during remission
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红白血病缓解期间正常干细胞的重新表达
DOI：
10.1182/blood.v62.1.177.bloodjournal621177
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发表时间：
1983
期刊：
影响因子：
20.3
通讯作者：
G. Gaetani
中科院分区：
文献类型：
--
作者：
A. Ferraris;L. Canepa;C. Mareni;G. Baule;T. Meloni;E. Salvidio;G. Forteleoni;G. Gaetani
研究了一例红白血病患者，其X-连锁酶葡萄糖-6-磷酸脱氢酶（G6 PD）的地中海变体为杂合子，以确定发生疾病的祖细胞的数量和类型。通过正常和地中海型G6 PD对2-脱氧葡萄糖-6-磷酸（2dG 6P）的不同利用率来评估G6 PD嵌合性。红白血病是一种涉及红系和髓系共同的前体细胞的克隆性疾病。在强化化疗后，造血细胞群体中嵌合体表型的再现表明非单克隆造血恢复。
A patient with erythroleukemia and heterozygous for the Mediterranean variant of the X-linked enzyme glucose-6-phosphate dehydrogenase (G6PD) was studied to determine the number and type of progenitor cells in which the disease arose. G6PD mosaicism was assessed by the different rate of utilization of 2-deoxy-glucose-6-phosphate (2dG6P) by normal and Mediterranean variants of G6PD. Erythroleukemia is established as a clonal disease involving a precursor cell common to the erythroid and myeloid lines. After intensive chemotherapy, restoration of nonmonoclonal hemopoiesis is achieved, as indicated by the reappearance of the mosaic phenotype in hemopoietic cell populations.