HIPPOCAMPAL SCLEROSIS AND HUMAN-MEMORY
HIPPOCAMPAL SCLEROSIS AND HUMAN-MEMORY
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DOI：
10.1001/archneur.1993.00540040051014
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发表时间：
1993-04-01
影响因子：
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通讯作者：
FINMORE, M
中科院分区：
文献类型：
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作者：
MILLER, LA;MUNOZ, DG;FINMORE, M
客观。-研究海马硬化对术前神经心理记忆测试的影响。方差分析和卡方检验用于比较患者组（回顾性划分）与对照组。医院癫痫单位。患者和其他参与者。-所有在过去18个月内因顽固性癫痫发作缓解而接受颞叶切除术的患者，如果符合以下标准，则被纳入：（1）年龄在15至55岁之间;（2）智商为80或更高;（3）左半球对语言起主导作用;（4）既往无脑外科手术;（5）有足够的海马组织供病理学研究，（6）除硬化外，无海马异常。符合所有这些标准的40例患者根据病理分类（有无海马硬化）和切除侧分组。根据年龄和教育程度与患者相匹配的10名正常对照受试者也被要求进行记忆测试。所有接近的受试者都同意参加这项研究。无。主要结果指标。-无结果。-没有一组在注意力或识别记忆方面表现出障碍。左侧海马硬化组、右侧海马硬化组和左侧无海马硬化组在学习成对词联想方面存在缺陷，但在要求延迟回忆信息的测试中，只有海马硬化患者受损。对于语言任务，延迟回忆缺陷仅限于左侧硬化症患者。海马硬化症损害了学习联想和延迟保留信息的能力。对于语言材料的学习和记忆，左侧海马比右侧海马更重要。
Objective.-To study the effects of hippocampal sclerosis on preoperative neuropsychological memory tests.Design.-Analyses of variance and chi2 tests were used to compare patient groups (divided retrospectively) with a control group.Setting.-Hospital epilepsy unit.Patients and Other Participants.-All patients who underwent a temporal lobectomy for intractable seizure relief during the preceding 18 months were included if the following criteria were met: (1) age was between 15 and 55 years; (2) IQ was 80 or greater; (3) the left hemisphere was dominant for speech; (4) there had been no previous brain surgery; (5) sufficient hippocampal tissue had been supplied for pathologic study; and (6) there was no hippocampal abnormality other than sclerosis. The 40 patients who met all of these criteria were divided into groups based on pathological classification (presence or absence of hippocampal sclerosis) and side of excision. Ten normal control subjects, matched to the patients based on age and education, were also asked to perform the memory tests. All subjects approached gave their informed consent to participate in the study.Interventions.-None.Main Outcome Measures.-None.Results.-No group demonstrated impairments on measures of attention or recognition memory. A deficit in learning paired-word associates was found for the left hippocampal sclerosis, right hippocampal sclerosis, and left no-hippocampal sclerosis groups, but on tests requiring the delayed recall of information, only patients with hippocampal sclerosis were impaired. For verbal tasks, the delayed recall deficit was limited to patients with left-sided sclerosis.Conclusions.-Hippocampal sclerosis impairs the ability to learn associations and to retain information over a delay interval. For the learning and retention of verbal material, the left hippocampus is more important than the right.