Role of the amygdala complex in early olfactory associative learning.
Role of the amygdala complex in early olfactory associative learning.
复制标题
杏仁核复合体在早期嗅觉联想学习中的作用。
DOI：
10.1037//0735-7044.107.2.254
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发表时间：
1993
影响因子：
1.9
通讯作者：
Wilson,DA
中科院分区：
文献类型：
--
作者：
Sullivan,RM;Wilson,DA
尽管新生大鼠的嗅觉联想调节使嗅球产生显着的结构和功能变化，但最近的证据表明球外回路必须参与存储这些早期记忆。目前的实验研究了杏仁核复合体在早期嗅觉学习中的作用。在出生后第 5 天（PN）进行双侧杏仁核损伤或假损伤。在 PN6，幼崽接受标准经典条件反射范式的训练，将气味与触觉刺激联系起来。对 PN7 的行为测试表明，杏仁核损伤会阻碍气味偏好，但对条件行为激活没有影响。类似大小的新皮质病变不会损害气味偏好。重要的是，杏仁核损伤对习得气味偏好的影响可以通过广泛的过度训练来逆转。这些结果表明，早在大鼠出生后第一周，杏仁核复合体就在调节联想学习中发挥着关键作用。（PsycINFO 数据库记录 (c) 2016 APA，保留所有权利）
Although olfactory associative conditioning in newborn rats produces marked structural and functional changes in the olfactory bulb, recent evidence suggests that extrabulbar circuits must be involved in storing these early memories. The present experiments examined the role of the amygdala complex on early olfactory learning. Bilateral amygdala lesions or sham lesions were performed on Postnatal Day (PN) 5. On PN6, pups were trained in a standard classical conditioning paradigm associating odor with tactile stimulation. Behavioral testing on PN7 revealed that amygdala lesions blocked odor preferences but had no effect on conditioned behavioral activation. Similar sized neocortical lesions did not impair odor preferences. Importantly, amygdala lesion effects on learned odor preferences could be reversed by extensive overtraining. These results suggest that the amygdala complex plays a critical role in modulating associative learning as early as the 1st postnatal week in the rat.(PsycINFO Database Record (c) 2016 APA, all rights reserved)