The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target
The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target
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DOI：
10.1016/j.plefa.2018.11.016
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发表时间：
2019-01-01
影响因子：
3
通讯作者：
Glatz, Jan F. C.
中科院分区：
文献类型：
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作者：
Chanda, Dipanjan;Neumann, Dietbert;Glatz, Jan F. C.
内源性大麻酰胺(AEA)和2-花生四烯酸甘油酯(2-AG)是内源性脂质介质，在包括心血管疾病在内的病理生理条件下发挥保护作用。在这篇简短的综述中，我们提供了一个将内源性大麻素信号与细胞和分子标志的控制联系起来的概念性框架，并对内源性大麻素信号的关键成分进行了分类，这些成分可能成为新疗法的靶点。新出现的图景不仅加强了内源性大麻素作为细胞新陈代谢的有效调节剂的作用，还揭示了内源性大麻素信号在机制上比最初认为的更复杂和多样化。
The endocannabinoids anandamide (AEA) and 2-arachidonoylglyerol (2-AG) are endogenous lipid mediators that exert protective roles in pathophysiological conditions, including cardiovascular diseases. In this brief review, we provide a conceptual framework linking endocannabinoid signaling to the control of the cellular and molecular hallmarks, and categorize the key components of endocannabinoid signaling that may serve as targets for novel therapeutics. The emerging picture not only reinforces endocannabinoids as potent regulators of cellular metabolism but also reveals that endocannabinoid signaling is mechanistically more complex and diverse than originally thought.