The long-term effect of perinatal asphyxia on hippocampal volumes
The long-term effect of perinatal asphyxia on hippocampal volumes
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DOI：
10.1038/s41390-018-0115-8
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发表时间：
2019-01-01
影响因子：
3.6
通讯作者：
van der Aa, Niek E.
中科院分区：
文献类型：
--
作者：
Annink, Kim, V;de Vries, Linda S.;van der Aa, Niek E.
背景：足月新生儿缺氧缺血性脑病（HIE）可导致记忆问题。海马体对长期情景记忆很重要。本研究的主要目的是探讨缺氧缺血性脑病对9 ~ 10岁儿童海马体积的影响。第二个目的是调查海马体积和以前发现的受损的记忆和认知功能之间的关联在当前cohol.METHODS：在总共26例轻度HIE，26例中度HIE，37名对照。测试智商和记忆力。获得3D体积MRI。对海马体积和颅内体积进行脑分割。确定了各组之间海马体积、记忆力和智商的差异。进行多变量线性回归分析，包括海马体积占颅内体积的百分比作为因变量。结果：与对照组相比，中度HIE的海马体积较小（p < 0.001），轻度HE的海马体积有减小的趋势。在多变量线性回归分析中，海马体积占颅内体积的百分比与长期visuospatial memory.CONCLUSION：中度HIE儿童海马体积小于对照组，轻度HIE后体积有缩小的趋势。海马体积减少与长期视觉空间记忆较差有关。
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) in term-born infants can lead to memory problems. The hippocampus is important for long-term episodic memory. The primary aim was to investigate the effect of HIE on hippocampal volumes in 9- to 10-year-old children. The secondary aim was to investigate the association between hippocampal volumes and previously found impaired memory and cognitive functions in the current cohort.METHODS: In total 26 children with mild HIE, 26 with moderate HIE, and 37 controls were included. The intelligence quotient (IQ) and memory were tested. A 3D-volumetric MRI was obtained. Brain segmentation was performed for hippocampal volumes and intracranial volume. The differences in hippocampal volumes, memory, and IQ between the groups were determined. Multivariable linear regression analyses were performed, including hippocampal volume as a percentage of intracranial volume as a dependent variable.RESULTS: Smaller hippocampal volumes were found in moderate HIE (p < 0.001), with a trend toward smaller volumes in mild HE, compared to controls. In multivariable linear regression analysis, hippocampal volume as a percentage of intracranial volume was significantly associated with long-term visuospatial memory.CONCLUSION: Children with moderate HIE had smaller hippocampal volumes than controls, with a trend toward smaller volumes following mild HIE. Reduced hippocampal volumes were associated with poorer long-term visuospatial memory.