Serotonin induces long-term depression at corticostriatal synapses.
Serotonin induces long-term depression at corticostriatal synapses.
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DOI：
10.1523/jneurosci.6250-10.2011
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发表时间：
2011-05-18
期刊：
影响因子：
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通讯作者：
Lovinger DM
中科院分区：
文献类型：
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作者：
Mathur BN;Capik NA;Alvarez VA;Lovinger DM
纹状体在运动控制和动作学习中具有重要作用，并且像许多脑区域一样，接收多个单胺能输入。我们已经研究了大鼠和小鼠皮质纹状体神经传递的多巴胺能调节，发现5-羟色胺（5-HT）激活5-HT 1b受体，导致谷氨酸释放和纹状体输出的长期抑制（LTD），我们称之为5-HT-LTD。5-HT-LTD是突触前介导的，cAMP通路依赖的，并可由内源性纹状体5-HT诱导，如通过应用选择性5-HT再摄取抑制剂（SSRI）所揭示的。5-HT-LTD与多巴胺/内源性大麻素依赖性LTD相互闭塞，表明这两种形式的LTD作用于相同的皮质纹状体末端。因此，多巴胺能和多巴胺能机制的存在，可能相互作用，持续雕刻皮质纹状体电路，潜在地影响动作学习和纹状体为基础的疾病。
The striatum has important roles in motor control and action learning and, like many brain regions, receives multiple monoaminergic inputs. We have examined serotonergic modulation of rat and mouse corticostriatal neurotransmission and find that serotonin (5-HT) activates 5-HT1b receptors resulting in a long-term depression (LTD) of glutamate release and striatal output that we have termed 5-HT-LTD. 5-HT-LTD is presynaptically mediated, cAMP pathway-dependent, and inducible by endogenous striatal 5-HT, as revealed by application of a selective 5-HT reuptake inhibitor (SSRI). 5-HT-LTD is mutually occlusive with dopamine/endocannabinoid-dependent LTD, suggesting that these two forms of LTD act on the same corticostriatal terminals. Thus, serotonergic and dopaminergic mechanisms exist that may interact to persistently sculpt corticostriatal circuits, potentially influencing action learning and striatal-based disorders.