The correlation of depression with functional activity in Parkinson's disease
The correlation of depression with functional activity in Parkinson's disease
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DOI：
10.1007/s004150050131
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发表时间：
1997-08-01
影响因子：
6
通讯作者：
Liu, HC
中科院分区：
文献类型：
--
作者：
Liu, CY;Wang, SJ;Liu, HC
我们通过三种方式对 109 名中国帕金森病 (PD) 患者进行了评估：针对抑郁和焦虑使用标准化精神病学访谈，针对运动障碍使用标准化神经学评估，以及针对认知障碍使用认知评估。 109 名痴呆症患者中的 6 名和另外两名患有器质性妄想症的患者被排除在进一步分析之外。其余101名PD患者根据DSM-III-R标准分为以下三组：重度抑郁症（n = 18），其他抑郁症（n = 25），包括心境恶劣障碍和未另有说明的抑郁症，以及无抑郁症（n = 58）。 109 名 PD 患者中，重度抑郁症的发生率为 16.5%，重度抑郁症和其他抑郁症的发生率合计为 42.2%。使用施瓦布和英格兰日常生活活动量表测量的百分点作为因变量来拟合多元回归模型，我们发现除了运动障碍和帕金森病的严重程度之外，较低的分数与抑郁症的诊断和汉密尔顿抑郁评定量表的较高分数显着相关。鉴于抑郁症的高频率以及抑郁症与日常功能活动表现之间的显着相关性，我们认为对 PD 患者共存抑郁症进行评估对于获得更好的治疗结果是必要的。
We evaluated 109 Chinese patients with Parkinson's disease (PD) in three ways: using a standardized psychiatric interview for depression and anxiety, using standardized neurological evaluation for motor disability, and using cognitive assessment for cognitive impairment. Six of the 109 patients who had dementia and another two afflicted with organic delusional disorder were excluded from further analysis. The remaining 101 PD patients were divided into the following three groups according to the DSM-III-R criteria: major depressive disorder (n = 18), other depressive disorders (n = 25) including dysthymic disorder and depressive disorder not otherwise specified, and no depression (n = 58). The frequency of major depressive disorder of the 109 PD patients was 16.5%, and the frequency of major and other depressive disorders, taken together, was 42.2%. Using the percentage points measured on the Schwab & England Activites of Daily Living Scale as the dependent variable to fit a multivariate regression model, we found the lower score significantly correlated with the diagnosis of depressive disorder and higher score of the Hamilton Depression Rating Scale, in addition to motor disability and disease severity of PD. Given the high frequency of depression and the significant correlation between depression and performance in daily functional activites, we believe that an evaluation of PD patients for coexisting depression is necessary for a better therapeutic outcome.