Intracerebral Hemorrhage Formation Under Direct Oral Anticoagulants Clinical and Translational Evidence
Intracerebral Hemorrhage Formation Under Direct Oral Anticoagulants Clinical and Translational Evidence
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DOI：
10.1161/strokeaha.118.023722
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发表时间：
2019-04-01
期刊：
影响因子：
8.3
通讯作者：
Schaefer, Jan Hendrik
中科院分区：
文献类型：
--
作者：
Foerch, Christian;Lo, Eng H.;Schaefer, Jan Hendrik
方法通过使用以下术语进行 PubMed 和 EMBASE 数据库搜索来确定临床和实验研究：（抗凝或 noac 或 vka 或华法林或达比加群或阿哌沙班或利伐沙班或艾多沙班）AND（脑出血或脑出血或血肿扩张）并作为实验研究的辅助搜索词：（动物或小鼠或大鼠或猪或兔或狗或豚鼠）或猫）（图1）。随着 DOAC 的引入，自 2010 年开始应用日期限制。此外，研究是从所选文章的参考文献列表中选择的。作者评估了所有出版物与本次审查主要目标的相关性。仅纳入报告入院时原发性 ICH 初始体积值的研究。此外，我们还对这些研究进行了荟萃分析。排除标准是脑微出血和创伤性或其他继发性脑出血。不考虑仅报告 VKA 或 DOAC（未进行比较）的研究。最后一次文献检索于2018年12月11日进行。
MethodsClinical and experimental studies were identified by performing a PubMed and EMBASE database search using the following term:(anticoagulation OR noac OR vka OR warfarin OR dabigatran OR apixaban OR rivaroxaban OR edoxaban) AND (intracerebral hemorrhage OR cerebral hemorrhage OR hematoma expansion) and as a secondary search term for experimental studies:(animal OR mouse OR rat OR pig OR rabbit OR dog OR guinea pig OR cat)(Figure 1). Date limits were applied starting in 2010 with the introduction of DOACs. In addition, studies were chosen from the reference lists of the selected articles. All publications were evaluated by the authors for relevance in regard to the primary objective of this review. Only studies reporting values for initial volume of primary ICH at hospital admission were included. Additionally, we included meta-analyses of these studies. Exclusion criteria were cerebral microbleeds and traumatic or other secondary ICH. Studies only reporting on VKA or DOACs (without comparisons) were not considered. The last literature search was conducted on December 11, 2018.