Batch fabrication of electrochemical sensors on a glycol-modified polyethylene terephthalate-based microfluidic device
Batch fabrication of electrochemical sensors on a glycol-modified polyethylene terephthalate-based microfluidic device
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DOI：
10.1016/j.bios.2020.112521
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发表时间：
2020-11-01
影响因子：
12.6
通讯作者：
Zhou, H. Susan
中科院分区：
文献类型：
--
作者：
Cui, Feiyun;Jafarishad, Hamed;Zhou, H. Susan
开发低成本的电化学微流控器件制造方法是将此类器件从基础研究转移到日常生活技术的迫切需要。本文中，具有嵌入式通道和金膜电极（GFE）的基于乙二醇改性的聚对苯二甲酸乙二醇酯（PETG）的微流体装置通过一步、低成本、简单且可批量生产的方法开发，并且通过可逆亲水性带基机制密封。容易获得的聚（甲基丙烯酸甲酯）（PMMA），聚对苯二甲酸乙二醇酯（聚酯，PET）和PETG被探索作为用于制造电化学传感器的基板选项。结果表明，PETG可以作为制备电极的优良基底。研究了器件的电化学稳定性和形貌。氧化还原离子（[Fe（CN）（6）]（3-/4-））和氧化还原有机化合物（多巴胺）都被用作模型分析物以证明器件的电化学性能。与电化学传感器集成的基于PETG的微流体装置可以用作用于检测生物和化学分析物的替代电化学装置。同时，报道了批量制备的基于PETG薄膜的柔性电化学传感器及其电化学性能。
Developing low-cost methods for the fabrication of electrochemical microfluidic devices is urgently needed for transferring such devices from fundamental research to daily-life technology. Herein, glycol-modified polyethylene terephthalate (PETG)-based microfluidic devices with embedded channels and gold film electrode (GFE) are developed by a one-step, low-cost, straightforward, and mass-producible method, and are sealed by a reversible hydrophilic tape-based mechanism. Easily accessible poly (methyl methacrylate) (PMMA), polyethylene terephthalate (polyester, PET), and PETG are explored as substrate options for fabricating electrochemical sensors. The results demonstrated that PETG can be an excellent substrate for fabricating the electrode. The electrochemical stability and morphology of the device are investigated. Both redox ions ([Fe(CN)(6)](3-/4-)) and redox organic compounds (dopamine) are used as model analytes to prove the electrochemical performance of the device. The PETG-based microfluidic devices integrated with electrochemical sensors can be used as alternative electrochemical devices for the detection of biological and chemical analytes. Meanwhile, batch-fabricated flexible electrochemical sensors based on PETG film and their electrochemical performance are reported.