Serum S100β increases in marathon runners reflect extracranial release rather than glial damage
Serum S100β increases in marathon runners reflect extracranial release rather than glial damage
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DOI：
10.1212/01.wnl.0000123092.97047.b1
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发表时间：
2004-05-11
期刊：
影响因子：
9.9
通讯作者：
Paulus, W
中科院分区：
文献类型：
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作者：
Hasselblatt, M;Mooren, FC;Paulus, W
在18名没有临床或实验室脑损伤迹象的马拉松运动员中，研究了颅外组织损伤对血清S100 β升高的作用。术后血清S100 β和肌酸激酶（CK）浓度升高（p < 0.001），曲线下面积高度相关（p = 0.001）。综上所述，运动后血清S100 β水平升高源于颅外来源。CK测定可提高S100 β作为急性创伤脑组织损伤标志物的特异性。
The contribution of extracranial tissue damage to serum S100beta increases was examined in 18 marathon runners without clinical or laboratory signs of brain damage. Postrace serum S100beta and creatine kinase (CK) concentrations increased (p < 0.001), and areas under the curve were highly correlated (p = 0.001). To conclude, serum S100 beta increases after running originate from extracranial sources. CK determination may improve specificity of S100 beta as a marker of brain tissue damage in acute trauma.