Epithelial cell proliferative activity and oral cancer progression
Epithelial cell proliferative activity and oral cancer progression
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上皮细胞增殖活性与口腔癌进展
作者：
Peter Thomson;J. Soames;C. Booth;J. A. O'Shea
摘要。在临床实践中，对口腔癌和癌前病变的行为和进展进行准确、预测性的评估仍然是难以捉摸的。对10例已知临床结果的口腔病变患者（治疗后3年）的档案组织标本进行了组织病理学检查，并测定了Ki67、细胞周期蛋白A和组蛋白mRNA细胞周期标志物的增殖细胞标记指数（LIs）。虽然组蛋白mRNA标记最终被证明是不可靠的，但Ki67和细胞周期蛋白A LIs都显示出明显的增强标记趋势，在越来越多的发育不良和肿瘤组织中发生，特别强调在异常组织中的基底上标记。也许最重要的是观察到在临床预后较差的病变中，如复发性疾病或颈部淋巴结转移的患者，li和基底上标记增加。因此，测量个体口腔上皮发育不良病变或侵袭性鳞状细胞癌的细胞增殖活性可能为临床结果提供独特的预测性信息。
Abstract. Accurate, predictive assessment of the behaviour and progression of oral cancers and precancers remains elusive in clinical practice. Archival tissue specimens from 10 previously treated patients with oral lesions of known clinical outcome (3 years post‐treatment) were re‐examined histopathologically, and proliferative cell labelling indices (LIs) determined for Ki67, cyclin A and histone mRNA cell cycle markers. While histone mRNA labelling ultimately proved unreliable, both Ki67 and cyclin A LIs demonstrated a clear trend for enhanced labelling to occur in increasingly dysplastic and neoplastic tissue, with particular emphasis on suprabasal labelling in abnormal tissue. Perhaps of greatest significance was the observation of increased LIs and suprabasal labelling in lesions with poor clinical outcome, such as patients developing recurrent disease or cervical lymph node metastasis. Measurement of cell proliferative activity in individual oral epithelial dysplastic lesions or invasive squamous cell carcinomas may thus provide unique, predictive information on clinical outcome.