Biodegradable injectable polyurethanes: Synthesis and evaluation for orthopaedic applications
Biodegradable injectable polyurethanes: Synthesis and evaluation for orthopaedic applications
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DOI：
10.1016/j.biomaterials.2008.06.021
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发表时间：
2008-10-01
期刊：
影响因子：
14
通讯作者：
Carbone, Tania
中科院分区：
文献类型：
--
作者：
Adhikari, Raju;Gunatillake, Pathiraja A.;Carbone, Tania
可生物降解的聚氨酯在组织工程和其他医疗植入应用的可注射或预成型支架的设计中具有优势。我们开发了两部分可注射预聚物系统（预聚物 A 和 13），由乳酸和乙醇酸基聚酯星形多元醇、季戊四醇 (PE) 和赖氨酸二异氰酸乙酯 (ELDI) 组成。这项研究报告了一系列专为骨科应用开发的交联聚氨酯的配方和性能。预聚物 A 基于 PE 和 ELDI。聚酯多元醇（预聚物B）基于PE和DL-乳酸（PEDLLA）或PE和乙醇酸（PEGA），分子量分别为456和453。通过混合和固化预聚物 A 和 B 制备了几种交联的多孔和无孔聚氨酯，并评估了它们的机械和热性能、体外（PBS/37 ℃/pH 7.4）和体内（羊双边）降解。还研究了掺入 β-磷酸三钙（β-TCP，5 微米，10 重量％）的效果。固化的聚合物表现出高压缩强度（100190 MPa）和模量（1600-2300 MPa）。 beta-TCP 改善了基于 PEDLLA 的聚氨酯的机械性能，并延缓了体外和体内降解的发生。绵羊研究结果表明，可注射形式和预固化形式的聚合物不会引起任何手术困难或任何不良组织反应。随着植入时间延长至 6 个月，观察到新骨生长和聚合物逐渐降解的证据。 (c) 2008 Elsevier Ltd. 保留所有权利。
Biodegradable polyurethanes offer advantages in the design of injectable or preformed scaffolds for tissue engineering and other medical implant applications. We have developed two-part injectable prepolymer systems (prepolymer A and 13) consisting of lactic acid and glycolic acid based polyester star polyols, pentaerythritol (PE) and ethyl lysine diisocyanate (ELDI). This study reports on the formulation and properties of a series of cross linked polyurethanes specifically developed for orthopaedic applications. Prepolymer A was based on PE and ELDI. Polyester polyols (prepolymer B) were based on PE and DL-lactic acid (PEDLLA) or PE and glycolic acid (PEGA) with molecular weights 456 and 453, respectively. Several cross linked porous and non-porous polyurethanes were prepared by mixing and curing prepolymers A and B and their mechanical and thermal properties, in vitro (PBS/37 degrees C/pH 7.4) and in vivo (sheep bi-lateral) degradation evaluated. The effect of incorporating beta-tricalcium phosphate (beta-TCP, 5 microns, 10 wt.%) was also investigated. The cured polymers exhibited high compressive strength (100190 MPa) and modulus (1600-2300 MPa). beta-TCP improved mechanical properties in PEDLLA based polyurethanes and retarded the onset of in vitro and in vivo degradation. Sheep study results demonstrated that the polymers in both injectable and precured forms did not cause any surgical difficulties or any adverse tissue response. Evidence of new bone growth and the gradual degradation of the polymers were observed with increased implant time up to 6 months. (c) 2008 Elsevier Ltd. All rights reserved.