Evaluation of the Toxicity of Anti-Inflammatory Drugs
Evaluation of the Toxicity of Anti-Inflammatory Drugs
复制标题
抗炎药物的毒性评价
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
B. Mitchell
中科院分区：
文献类型：
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作者：
P. Dodge;D. A. Brodie;B. Mitchell
当认识到美国约有4000万人患有关节炎时，抗炎药物毒性问题的重要性就显现出来了（Emmitt，1975）。这一人口中约有一半人接受医疗护理，另一半人自我治疗;在接受医疗护理的人中，三分之一需要长期服用药物，其余人需要间歇服用药物。关节炎是世界范围内的一种流行病：如果药物相关副作用的发生率为10%（保守估计），每年接受药物治疗的患者中可能有500万人发生药物诱导的毒性，而对于那些自行服用抗炎药（如阿司匹林）的患者，至少是这个数字的两倍。
The importance of the problem of anti-inflammatory drug toxicity comes into perspective when it is recognised that there are approximately 40 million people in the United States suffering from arthritis (Emmitt, 1975). About half of this population is under medical care and the other half is self-treated; of those under medical care, one-third require chronic drug administration, and the remainder, intermittent administration. Arthritis is a prevalent disease worldwide: if there were a 10% incidence of drug-related side-effects (a conservative estimate), there would be the possibility of drug-induced toxicity in 5 million patients per year of those under medical treatment, and at least twice this number for those patients who would self-administer an anti-inflammatory drug such as aspirin.