Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides.
Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides.
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修饰的核酸：扩大功能性寡核苷酸的能力。
DOI：
10.3390/molecules25204659
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发表时间：
2020-10-13
期刊：
影响因子：
--
通讯作者：
Milam VT
中科院分区：
文献类型：
--
作者：
Ochoa S;Milam VT
在过去的三十年里，寡核苷酸作为探针、分子配体甚至催化剂在治疗和诊断应用中得到了广泛的研究。然而，天然核酸的狭窄化学库对寡核苷酸的功能范围施加了限制。克服这种化学多样性缺陷的最初努力包括对糖-磷酸骨架或侧基的保守修饰，并导致体内性能增强。更重要的是，后来的工作涉及其他修改导致实现新的功能特性超出了最初的预期治疗和诊断前景。这些结果激发了对越来越多的奇异化学物质的探索，这些化学物质与具有非自然物理化学性质的典型核酸化学结构高度不同。在这篇综述中，作者强调了修饰的寡核苷酸的最新进展，并推动设计新的基于核酸的配体和催化剂，具有天然寡核苷酸无法获得的特殊工程功能。
In the last three decades, oligonucleotides have been extensively investigated as probes, molecular ligands and even catalysts within therapeutic and diagnostic applications. The narrow chemical repertoire of natural nucleic acids, however, imposes restrictions on the functional scope of oligonucleotides. Initial efforts to overcome this deficiency in chemical diversity included conservative modifications to the sugar-phosphate backbone or the pendant base groups and resulted in enhanced in vivo performance. More importantly, later work involving other modifications led to the realization of new functional characteristics beyond initial intended therapeutic and diagnostic prospects. These results have inspired the exploration of increasingly exotic chemistries highly divergent from the canonical nucleic acid chemical structure that possess unnatural physiochemical properties. In this review, the authors highlight recent developments in modified oligonucleotides and the thrust towards designing novel nucleic acid-based ligands and catalysts with specifically engineered functions inaccessible to natural oligonucleotides.
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影响因子：
21.8
作者：
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通讯作者：
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DOI：
10.1016/j.bbrc.2012.01.127
发表时间：
2012-03-02
影响因子：
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作者：
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通讯作者：
Fuerste, Jens P.
DOI：
10.1073/pnas.1615475114
发表时间：
2017-03-14
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
4.6
作者：
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