Validation of dynamic contrast-enhanced magnetic resonance imaging-derived vascular permeability measurements using quantitative autoradiography in the RG2 rat brain tumor model
Validation of dynamic contrast-enhanced magnetic resonance imaging-derived vascular permeability measurements using quantitative autoradiography in the RG2 rat brain tumor model
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DOI：
10.1593/neo.07289
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发表时间：
2007-07-01
期刊：
影响因子：
4.8
通讯作者：
Butman, John A.
中科院分区：
文献类型：
--
作者：
Ferrier, Moira C.;Sarin, Hemant;Butman, John A.
动态对比增强磁共振成像（DCE-MRI）被广泛用于评估肿瘤渗透性，但测量结果尚未在脑肿瘤中得到直接验证。我们的目的是将来自DCE-MRI的前向泄漏K-transs估计值与使用[C-14]氨基异丁酸定量放射自显影（[C-14] AIB QAR）获得的估计值K进行比较，[C-14] AIB QAR是一种评价血肿瘤屏障渗透性的既定方法。在肿瘤植入后9至11天，在5只大鼠中进行DCE-MRI和[C-14] AIB QAR。使用三参数一般动力学模型和测量的血管输入函数，根据DCE-MRI估计肿瘤中的K反式。使用与用于估计KtransK的区域密切对应的感兴趣区域（ROI）从QAR数据估计Ki。对于两组独立的中央肿瘤ROI，KtransK和Ki彼此相关（R = 0.905，P = 0.035; R = 0.933，P = 0.021）。在另外6只大鼠中，在两种情况下估计K transs以显示再现性（组内系数= 0.9993;变异系数= 6.07%）。来自DCE-MRI的体内血液-肿瘤渗透性参数是可重现的，并且与用于定量血液肿瘤屏障渗透性的金标准[C-14] AIB QAR相关。
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used to evaluate tumor permeability, yet measurements have not been directly validated in brain tumors. Our purpose was to compare estimates of forward leakage K-trans derived from DCE-MRI to the estimates K obtained using [C-14] aminoisobutyric acid quantitative autoradiography ([C-14] AIB QAR), an established method of evaluating blood - tumor barrier permeability. Both DCE- MRI and [C-14] AIB QAR were performed in five rats 9 to 11 days following tumor implantation. K trans in the tumor was estimated from DCE- MRI using the threeparameter general kinetic model and a measured vascular input function. Ki was estimated from QAR data using regions of interest (ROI) closely corresponding to those used to estimate K trans. K trans and Ki correlated with each other for two independent sets of central tumor ROI (R = 0.905, P =.035; R = 0.933, P =.021). In an additional six rats, K trans was estimated on two occasions to show reproducibility (intraclass coefficient = 0.9993; coefficient of variance = 6.07%). In vivo blood - tumor permeability parameters derived from DCE-MRI are reproducible and correlate with the gold standard for quantifying blood tumor barrier permeability, [C-14] AIB QAR.