Natural Estrogen Receptor Modulators and Their Heterologous Biosynthesis
Natural Estrogen Receptor Modulators and Their Heterologous Biosynthesis
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天然雌激素受体调节剂及其异源生物合成
DOI：
10.1016/j.tem.2018.11.002
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发表时间：
2019-01
影响因子：
10.9
通讯作者：
Jiali Yang;Lingrong Wen;Yue-ming Jiang;Bao Yang
中科院分区：
文献类型：
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作者：
Jiali Yang;Lingrong Wen;Yue-ming Jiang;Bao Yang
雌激素受体（ER）是一种与人体生理发育和代谢密切相关的转录因子。它们还在癌症和代谢性疾病的治疗中发挥重要作用。与ER相互作用的化学物质可用于治疗疾病和维持健康。植物雌激素是一种具有重要ER调节活性的天然化合物。然而，由于植物雌激素在自然界中通常以低量存在，近年来异源生物合成技术迅速发展，以满足所需的治疗量的需求。在这篇综述中，植物雌激素作为ER调节剂的性能与生物合成技术的最新进展一起沿着描述。
Estrogen receptors (ERs) are transcription factors highly involved in physiological development and metabolism in the human body. They also play important roles in the treatment of cancer and metabolic diseases. Chemicals that interact with ERs can be used to treat diseases and maintain health. Phytoestrogens are natural chemicals that have been documented to possess significant ER modulatory activities. However, since phytoestrogens usually exist at low quantities in nature, heterologous biosynthesis techniques have quickly developed in recent years in order meet the demands for needed therapeutic amounts. In this review, the performance of phytoestrogens as ER modulators is described along with recent advances in biosynthesis techniques.