Ultrastructural and immunohistological characterization of the SIRC corneal cell line.
Ultrastructural and immunohistological characterization of the SIRC corneal cell line.
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SIRC 角膜细胞系的超微结构和免疫组织学特征。
DOI：
10.1007/bf02624618
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Martin,JH
中科院分区：
文献类型：
--
作者：
Niederkorn,JY;Meyer,DR;Ubelaker,JE;Martin,JH
A widely utilized rabbit corneal cell line, SIRC, was characterized ultrastructurally and immunohistologically. Although SIRC cells are often described as being of epithelial origin, important ultrastructural and antigenic characteristics indicate that these cells are fibroblastic and not epithelial. SIRC cells lack desmosomes, cytoplasmic filaments, and cytokeratin—structures that are characteristic of corneal epithelial cells. By contrast, the dendritic morphology, presence of vimentin, and the extensive dense accumulations of ribosomes and rough endoplasmic reticulum are consistent with a fibroblastic phenotype. Collectively, the morphology, ultrastructural features, and antigenic composition favor the hypothesis that SIRC cells are fibroblastic cells (keratocytes) and not corneal epithelial cells.
