Resistance to Listeria monocytogenes in mice: genetic control by genes that are not linked to the H-2 complex.
Resistance to Listeria monocytogenes in mice: genetic control by genes that are not linked to the H-2 complex.
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小鼠对单核细胞增生李斯特氏菌的抵抗力：通过与 H-2 复合物无关的基因进行遗传控制。
DOI：
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发表时间：
1979
影响因子：
6.4
通讯作者：
D. Sachs
中科院分区：
文献类型：
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作者：
E. Skamene;P. Kongshavn;D. Sachs
给几个近交系小鼠注射单核细胞增殖性李斯特氏菌后，测定了两个抗性参数：半数致死量和对脾细菌增殖的抑制作用。受试品系可分为两组：抗性C57BL/10SN小鼠和敏感的A/J和DBA/2J小鼠。小鼠的同源抗性品系是因为它们在抗性品系C57BL/10SN的背景上表达敏感品系(H-2a或H-2d)的H-2单倍型。B10.A/SGSN(H-2a)和B10.D2/Sn(H-2d)小鼠与其背景品系小鼠的抵抗力相同，但明显高于提供其H-2基因座的品系(A/J或DBA/2J)。因此，小鼠对李斯特氏菌的抗性虽然是遗传控制的，但并不是由与H-2单倍型连锁的基因(S)控制的。另一方面，C57BL/10Sn(H-2b)小鼠对李斯特菌抗原的特异性免疫水平(足垫反应)高于A/J和B10.A/SGSN(H-2a)小鼠或DBA/2J和B10.D2/Sn(H-2d)小鼠。这一观察结果表明，对李斯特菌的特异性免疫存在H-2连锁。
After mice of several inbred strains were injected with Listeria monoyctogenes, two parameters of resistance, the 50% lethal dose and the suppression of bacterial proliferation in spleen, were determined. The strains of mice tested could be segregated into two groups: the resistant C57BL/10Sn mice and the sensitive A/J and DBA/2J mice. Congenic resistant strains of mice were used because they would express the H-2 haplotype of the sensitive strains (H-2a or H-2d) on the background of a resistant strain, C57BL/10Sn. Both the B10.A/SgSn (H-2a) and the B10.D2/Sn (H-2d) mice were as resistant as mice from their background strain and were significantly more resistant than the strains that donated their H-2 locus (A/J or DBA/2J). Therefore, the resistance of mice to Listeria, although genetically controlled, is not controlled by gene (s) linked to the H-2 haplotype. On the other hand, the level of specific immunity to listeria antigens (as indicated by the footpad reaction) was higher in the C57BL/10Sn (H-2b) mice than in either the A/J and B10.A/SgSn (H-2a) mice or the DBA/2J and B10.D2/Sn (H-2d) mice. This observation suggests an H-2 linkage of specific immunity to Listeria.