Ecstasy:: a common cause of severe acute hepatotoxicity
Ecstasy:: a common cause of severe acute hepatotoxicity
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DOI：
10.1016/s0168-8278(98)80056-1
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发表时间：
1998-09-01
影响因子：
25.7
通讯作者：
Rodés, J
中科院分区：
文献类型：
--
作者：
Andreu, V;Mas, A;Rodés, J
背景/目标：摇头丸是一种合成安非他明，最近被确定为急性肝损伤的可能原因。这种药物被年轻人服用，对改善社交能力有显着作用。迷魂药相关的严重肝损害的程度是未知的data.Methods：62例急性肝功能衰竭患者的临床历史承认重症监护肝病病房1994年1月至1996年12月仅仅审查，以评估的频率，流行病学，临床和组织学特征和迷魂药引起的重型肝炎的结果，结果：在此期间，5名患者（8%）因迷魂药诱导的急性肝衰竭入院，占药物肝毒性病例的31%，迷魂药是25岁以下患者肝损伤的第二大常见原因，在这部分患者中为20%，排除病毒病因后为36%。所有患者均为急性起病的严重肝病，伴有黄疸、血清转氨酶活性高峰、低血糖和低凝血酶原活动度，但无肝性脑病。在所有情况下，从3至12 months.Conclusions观察到完全恢复：ecceptide是负责相对较高数量的急性肝功能衰竭的年轻人。因此，应在所有原因不明的重型肝炎患者中研究该药的使用。必须努力向青年人宣传摇头丸消费的风险。
Background/Aims: Ecstasy is a synthetic amphetamine recently identified as a possible cause of acute liver injury This drug is consumed by young people and has a marked effect on improving sociability. The extent of ecstasy-associated severe hepatic damage is unknown to date.Methods: The clinical histories of 62 patients with acute liver failure admitted to the Intensive Care Liver Unit between January 1994 and December 1996 mere reviewed to assess the frequency the epidemiological, clinical and histological characteristics and the outcome of ecstasy-induced severe hepatitis,Results: Over this period of time, five patients (8%) were admitted because of ecstasy-induced acute liver failure, representing 31% of the cases with drug hepatotoxicity, Ecstasy was the second most common cause of liver injury in patients under the age of 25 years, being 20% in this subset of patients and 36% after ruling out the cases of viral etiology. All the patients had severe liver disease of acute onset, with jaundice, high peak of serum transaminases activity, hypoglycemia and low prothrombin activity, but no hepatic encephalopathy. Full recovery was observed in all cases from 3 to 12 months.Conclusions: Ecstasy is responsible for a relatively high number of cases of acute liver failure in young people. Therefore, the use of this drug should be investigated in all patients with severe hepatitis of unclear origin. Efforts must be made to advise young people of the risks of ecstasy consumption.