Long-Term Survival After Esophagectomy for Early Esophageal Squamous Cell Carcinoma in Linxian, China
Long-Term Survival After Esophagectomy for Early Esophageal Squamous Cell Carcinoma in Linxian, China
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DOI：
10.1002/jso.21953
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发表时间：
2011-08-01
影响因子：
2.5
通讯作者：
Qiao, You-Lin
中科院分区：
文献类型：
--
作者：
Song, Philip I.;Liang, Hao;Qiao, You-Lin
背景和目的：河南省林县是世界上食管癌发病率最高的地区之一。对于早期发现筛查中发现的早期肿瘤性病变行食管切除术后的长期生存率知之甚少。方法：对林县315例早期食管鳞状细胞癌（ESCC）患者行食管癌切除术后的长期生存率进行分析，并与2例年龄、性别匹配的健康对照组进行Kaplan-Meier生存分析。病例组和对照组的10年生存率分别为77%和64%，差异无统计学意义（P - 0.33）。不同年龄、性别患者的生存率差异无统计学意义（P > 0.05）。原位食管癌的病例生存率明显高于浸润性食管癌的病例（P = 0.035）。结论：早期食管癌接受食管切除术的病例生存率与年龄和性别匹配的对照组生存率无显著差异。早期干预可能提高这些患者的生存率，否则他们很可能发展为晚期食管癌。早期筛查和干预在食管癌高危地区（如中国林县）具有高度相关性。外科肿瘤学杂志2011;104：176-180。(C)2011 Wiley-Liss，Inc.
Background and Objectives: Linxian in Henan Province, China, has among the highest rates of esophageal cancer worldwide. Little is known about long-term survival after esophagectomy for early neoplastic lesions found during early detection screening. A long-term survival analysis was performed for 315 patients from Linxian who received esophagectomy for early esophageal squamous cell carcinoma (ESCC).Methods: Cases that received esophagectomy for early ESCC were age-and gender-matched with two healthy controls, and Kaplan-Meier survival analyses were performed for both groups.Results: Ten-year survival was 77% for cases and 64% for controls, and this difference was not statistically significant (P - 0.33). There were no significant differences in survival based on age or gender (P > 0.05). Cases with ESCC in situ had significantly better survival than cases with invasive ESCC (P = 0.035).Conclusions: Survival of cases who received esophagectomy for early ESCC was not significantly different from survival of age-and gender-matched controls. Early intervention probably improved survival rates for these patients who otherwise would most likely have developed advanced esophageal carcinoma. Early screening and intervention are highly relevant in areas with a high risk of esophageal cancer such as Linxian, China. J. Surg. Oncol. 2011;104:176-180. (C) 2011 Wiley-Liss, Inc.