Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case-control study.
Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case-control study.
复制标题
DOI：
10.1016/j.numecd.2016.03.005
复制
发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Yanna Zhu;Baoting He;Jin Jing;Jin Ma;Xiuhong Li;Wenhan Yang;Yu Jin;Yu-Lan Chen
中科院分区：
文献类型：
--
作者：
Yanna Zhu;Baoting He;Jin Jing;Jin Ma;Xiuhong Li;Wenhan Yang;Yu Jin;Yu-Lan Chen
背景和目的铁代谢在心脏代谢疾病的发展中起着至关重要的作用;然而，心脏代谢危险因素（CMRFs）和铁调素以及其他铁参数之间的关系在儿童中仍然不清楚。本研究的目的是比较有和没有CMRF的儿童之间的循环铁调素水平和铁代谢，并探讨这些铁参数与CMRF之间的相关性。方法和结果对1126名7-14岁儿童进行了病例对照研究，病例组（n= 563）CMRF和健康对照组（n= 563）。铁参数，脂质和人体测量特征进行了评价。关于人口统计学、饮食和体育活动的信息由儿童报告或父母报告。CMRFs患儿血清铁调素水平高于健康对照组，血清铁、转铁蛋白和可溶性转铁蛋白受体（sTfR）水平低于健康对照组（P< 0.001）。铁调素、转铁蛋白和sTfR水平升高的儿童高密度脂蛋白（HDL）水平降低的比值比（OR）分别为2.03、0.21和0.33（P< 0.05）。此外，心脏代谢风险的OR为0.50（95%可信区间（CI）：0.30- 0.85，P < 0.05），0.22（95%CI：0.12，0.42，P < 0.01）和0.19（95%置信区间：血清铁、转铁蛋白和sTfR水平升高的儿童中，铁调素水平升高，而铁、转铁蛋白、sTfR水平升高的儿童中，铁调素水平升高的儿童中，铁、转铁蛋白、sTfR水平升高的儿童中，铁调素水平升高的儿童中，sTfR水平升高的儿童中，铁调素水平升高的儿童中，sTfR水平升高的儿童中，铁调素水平升高的儿童中，sTfR水平升高的儿童中，铁调素水平升高的儿童中，铁、转铁蛋白、sTfR水平升高的儿童中，sTfR水平升高的儿童中，铁调素水平升高的儿童中，sTfR水平升高的儿童中，铁调素水平升高的儿童中，sTfR水平升高的儿童中，铁调素水平升高的儿童中，CMRF患儿sTfR较正常儿童低。铁调素与低HDL水平的风险呈正相关，而转铁蛋白和sTfR水平与低HDL水平的风险呈负相关。此外，血清铁、转铁蛋白和sTfR水平与心脏代谢风险呈负相关。
Background and aimsIron metabolism plays a crucial role in the development of cardiometabolic disease; however, the association between cardiometabolic risk factors (CMRFs) and hepcidin as well as other iron parameters remains unclear in children. The aims of this study were to compare the circulating hepcidin levels and iron metabolism between children with and without CMRFs and to investigate the association between those iron parameters and CMRFs.Methods and resultsA case–control study was conducted among 1126 children aged 7–14 years in the case group (n= 563) with CMRFs and the healthy control group (n= 563). Iron parameters, lipids, and anthropometric characteristics were evaluated. The information on demographics, diet, and physical activities was either children reported or parent reported. Compared with the healthy controls, children with CMRFs had higher levels of hepcidin and lower levels of serum iron, transferrin, and soluble transferrin receptor (sTfR;P< 0.001). Besides, the odds ratios (ORs) for low levels of high-density lipoprotein (HDL) were 2.03, 0.21, and 0.33 in children with higher hepcidin, transferrin, and sTfR levels (P< 0.05). Furthermore, ORs for cardiometabolic risk were 0.50 (95% confidence interval (CI): 0.30–0.85,P< 0.05), 0.22 (95% CI: 0.12, 0.42,P< 0.01) and 0.19 (95% CI: 0.10, 0.36,P< 0.01) in children with higher serum iron, transferrin, and sTfR levels, respectively.ConclusionThe levels of hepcidin were higher, while those of iron, transferrin, and sTfR were lower in children with CMRF. Hepcidin was positively associated with the risk of low HDL levels, whereas transferrin and sTfR levels negatively correlated with the risk of low HDL levels. In addition, serum iron, transferrin, and sTfR levels were negatively associated with cardiometabolic risk.