A computational model for motor pattern switching between taste-induced ingestion and rejection oromotor behaviors.
A computational model for motor pattern switching between taste-induced ingestion and rejection oromotor behaviors.
复制标题
味觉诱导的摄入和拒绝口腔运动行为之间运动模式切换的计算模型。
DOI：
10.1007/s10827-006-0009-3
复制
发表时间：
2007
影响因子：
1.2
通讯作者：
Terman,DavidH
中科院分区：
文献类型：
--
作者：
Venugopal,Sharmila;Travers,JosephB;Terman,DavidH
在中央模式生成器中切换活动模式的机制是产生不同运动行为的基础。基于已知的脑干底物调节摄取和拒绝的口头成分，我们使用计算技术构建了一个假想的多功能网络，它在摄取(舔)和拒绝(张口)的运动输出之间切换。该网络是基于Hodgkin-Huxley形式的单个神经元的基于单室电导的模型构建的。利用快慢归约和几何分析，我们描述了一种在舔和张开之间进行模式切换的机制。该模型支持这样的假设，即网络连接的单一配置可以产生两种活动模式。它进一步预测，一些网络神经元的长期抑制可能会导致网络活动从舔到张口。
The mechanism of switching activity patterns in a central pattern generator is fundamental to the generation of diverse motor behaviors. Based on what is known about a brainstem substrate mediating the oral components of ingestion and rejection, we use computational techniques to construct a hypothetical multifunctional network that switches between the motor outputs of ingestion (licking) and rejection (gaping). The network was constructed using single-compartment conductance-based models for individual neurons based on Hodgkin-Huxley formalism. Using a fast-slow reduction and geometric analysis we describe a mechanism for pattern switching between licks and gapes. The model supports the hypothesis that a single configuration of network connections can produce both activity patterns. It further predicts that prolonged inhibition of some network neurons could lead to a switch in network activity from licks to gapes.