Physical activity and the risk of Parkinson disease
Physical activity and the risk of Parkinson disease
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DOI：
10.1212/01.wnl.0000151960.28687.93
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发表时间：
2005-02-22
期刊：
影响因子：
9.9
通讯作者：
Ascherio, A
中科院分区：
文献类型：
--
作者：
Chen, H;Zhang, SM;Ascherio, A
目的：探讨更多的体力活动是否与降低帕金森病（PD）的风险相关。方法：作者前瞻性地跟踪了48574名男性和77254名女性，他们提供了1986年或成年早期的身体活动信息。在随访期间，共发现252例（男性）和135例（女性）PD病例。结果：在男性中，较大的基线体力活动与较低的PD风险相关；与最低五分位数相比，最高五分位数PD的多变量相对危险度（RR）为0.7 (95% CI 0.5 ~ 1.1， p值，趋势检验= 0.007)，排除前10年随访后仍存在负相关（RR = 0.5， p值，趋势检验= 0.02）。此外，成年早期剧烈运动也与男性PD风险呈负相关：与经常运动少于或等于2个月/年的男性相比，剧烈运动大于或等于10个月的男性PD风险降低60% （RR = 0.4； p值，趋势检验= 0.005）。在女性中，基线时评估的体力活动与PD风险无关，而成年早期的剧烈运动往往与晚年PD风险呈负相关（最高与最低类别，RR = 0.5, 95% CI 0.2至1.4；p值，趋势检验= 0.06）。结论：这项研究表明，高水平的体育锻炼可能会降低男性帕金森病（PD）的风险，或者易患帕金森病的男性在成年早期倾向于避免剧烈的体育锻炼。
Objective: To investigate whether greater physical activity is associated with a lower risk of Parkinson disease (PD). Methods: The authors prospectively followed 48,574 men and 77,254 women who provided information on physical activity in 1986 or in early adulthood. During the follow-up, a total of 252 ( male) and 135 ( female) incident PD cases were identified. Results: In men, greater baseline physical activity was associated with a lower PD risk; compared with the lowest quintile, the multivariate relative risk (RR) of PD for the highest quintile was 0.7 (95% CI 0.5 to 1.1; p value, test for trend = 0.007), and the inverse association was still present after excluding the first 10 years of follow-up ( RR = 0.5; p value, test for trend = 0.02). Further, strenuous exercise in early adult life was also inversely related to PD risk in men: compared with men who regularly exercised less than or equal to2 months/year, those with greater than or equal to10 months of strenuous exercise had a 60% lower PD risk (RR = 0.4; p value, test for trend = 0.005). In women, physical activity assessed at baseline was not related to PD risk, whereas strenuous exercise in early adulthood tended to be inversely related to PD risk later in life ( highest vs lowest categories, RR = 0.5, 95% CI 0.2 to 1.4; p value, test for trend = 0.06). Conclusion: This study suggests either that higher levels of physical activity may lower the risk of Parkinson disease ( PD) in men or that men predisposed to PD tend to avoid strenuous physical activity in their early adult years.