Fibrinolysis resistance after liver transplant as a predictor of early infection.
Fibrinolysis resistance after liver transplant as a predictor of early infection.
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DOI：
10.1016/j.amjsurg.2022.09.011
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发表时间：
2022-12
影响因子：
3
通讯作者：
Moore, Hunter B.
中科院分区：
文献类型：
--
作者：
Rodriguez, Ivan E.;Yoeli, Dor;Ferrell, Tanner;Jiang, Jessie G.;Truong, Ronald;Nydam, Trevor L.;Adams, Megan A.;Cullen, J. Michael;Pomfret, Elizabeth A.;Moore, Hunter B.
关键词：
感染是肝移植（LT）中发病的主要原因。考虑到脓毒症时纤溶系统的改变，我们研究了纤溶抵抗（FR）与移植后感染的关系。使用血栓弹力图（TEG）定量纤维蛋白溶解，并添加tPA以定量FR。FR定义为LY 30 = 0%，如果在POD 1或POD 5（tFR）时存在，则分层为一过性，如果在两种情况下都存在，则分层为持续性（pFR），或者如果不存在，则分层为无FR（nFR）。前瞻性入组了180例LT接受者。52例（29%）受者发生感染。72例有tFR; 37例有pFR; 71例有nFR。pFR受体的感染发生率显著更高（51% vs. 26% tFR vs. 20% nFR，p = 0.002）。pFR与移植后感染几率增加独立相关（调整OR 3.39，p = 0.009）。持续性纤维蛋白溶解抵抗与移植后感染风险增加相关。
Infection is a leading cause of morbidity in liver transplant (LT). Considering that the fibrinolytic system is altered in sepsis, we investigated the relationship between fibrinolysis resistance (FR) and post-transplant infection. Fibrinolysis was quantified using thrombelastography (TEG) with the addition of tPA to quantify FR. FR was defined as LY30 = 0% and stratified as transient if present on POD1 or POD5 (tFR), persistent (pFR) if present on both, or no FR (nFR) if absent. 180 LT recipients were prospectively enrolled. 52 (29%) recipients developed infection. 72 had tFR; 37 had pFR; and 71 had nFR. Recipients with pFR had significantly greater incidence of infections (51% vs. 26% tFR vs. 20% nFR, p = 0.002). pFR was independently associated with increased odds of post-transplant infection (adjusted OR 3.39, p = 0.009). Persistent fibrinolysis resistance is associated with increased risk of post-transplant infection.
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血小板功能的粘弹性测量，而不是纤维蛋白原功能可以预测创伤患者中对组织型纤溶酶原激活剂的敏感性。
DOI：
10.1111/jth.13067
发表时间：
2015-10
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Moore HB;Moore EE;Chapman MP;Gonzalez E;Slaughter AL;Morton AP;D'Alessandro A;Hansen KC;Sauaia A;Banerjee A;Silliman CC
通讯作者：
Silliman CC
影响因子：
3.9
作者：
Infanger L;Dibiasi C;Schaden E;Ulbing S;Wiegele M;Lacom C;Gratz J
通讯作者：
Gratz J
影响因子：
2.1
作者：
Bhutiani, Neal;Jones, Christopher M.;Martin, Robert C. G., II
通讯作者：
Martin, Robert C. G., II
DOI：
10.1073/pnas.2010229117
发表时间：
2020-09-08
影响因子：
11.1
作者：
Kang, Sujin;Tanaka, Toshio;Kishimoto, Tadamitsu
通讯作者：
Kishimoto, Tadamitsu
影响因子：
4.3
作者：
Mira JC;Brakenridge SC;Moldawer LL;Moore FA
通讯作者：
Moore FA