Biodegradable polymeric microcellular foams by modified thermally induced phase separation method
Biodegradable polymeric microcellular foams by modified thermally induced phase separation method
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DOI：
10.1016/s0142-9612(99)00073-3
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发表时间：
1999-10-01
期刊：
影响因子：
14
通讯作者：
Park, TG
中科院分区：
文献类型：
--
作者：
Nam, YS;Park, TG
提出了用于制造基于聚（L-乳酸）及其与 D-乳酸和/或乙醇酸的共聚物的各种可生物降解聚合物的多孔泡沫的热诱导相分离（TIPS）。通过系统地改变 TIPS 工艺中涉及的几个参数，例如聚合物类型和浓度、粗化条件、溶剂/非溶剂组成以及添加剂的存在，获得了不同的泡沫形态。所生产的泡沫具有微孔结构，平均孔径在 1 至 30 μm 之间，具体取决于工艺参数，并通过扫描电子显微镜 (SEM) 和压汞孔隙率测定法对其进行了表征。此外，Pluronic F127 用作添加剂致孔剂来控制孔隙的几何形状和尺寸。 (C) 1999 Elsevier Science Ltd. 保留所有权利。
Thermally induced phase separation (TIPS) for the fabrication of porous foams based on various biodegradable polymers of poly(L-lactic acid) and its copolymers with D-lactic acid and/or glycolic acid is presented. Diverse foam morphologies were obtained by systematically changing several parameters involved in the TIPS process, such as polymer type and concentration, coarsening conditions, solvent/nonsolvent composition, and the presence of an additive. The produced foams had microcellular structures with average pore diameters ranging from 1 to 30 mu m depending on the process parameters, which were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry. Additionally, Pluronic F127 was used as an additive porogen to control the pore geometry and size. (C) 1999 Elsevier Science Ltd. All rights reserved.