The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q).
The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q).
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人类酪氨酸激酶基因 (FER) 定位于 5 号染色体，并在髓性白血病中以 del(5q) 缺失。
DOI：
10.1159/000132929
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Groffen,J
中科院分区：
文献类型：
--
作者：
Morris,C;Heisterkamp,N;Hao,QL;Testa,JR;Groffen,J
最近分离并表征了SRC酪氨酸激酶基因家族的新成员（Hao等人，1989年）。这种FES/FPS相关基因，命名为FER，缺乏具有受体功能的酪氨酸激酶的跨膜和胞外结构域。FER在广泛的细胞类型中的表达表明在细胞内信号传导或分化过程中的一般作用。我们用原位杂交技术将FER定位在染色体5 q14 →q23上，并建议将其更精确地定位在5 q21 →q22带内。该区域邻近生长因子和受体的复杂结构域，许多生长因子和受体参与造血的调节。在急性髓性白血病或骨髓增生异常综合征患者中，FER定位在5号染色体上经常缺失的关键片段内，并在两名此类患者中显示缺失。它还映射到5 q22处的家族性结肠息肉病基因座附近。
A novel member of the SRC tyrosine kinase gene family was recently isolated and characterized (Hao et al., 1989). This FES/FPS-related gene, named FER, lacks the transmembrane and extracellular domains which characterize tyrosine kinases with receptor function. Expression of FER in a wide range of cell types indicates a general role in intracellular signalling or differentiation processes. We have now mapped FER to chromosome 5q14→q23 using in situ hybridization techniques and sug gest a more precise location within bands 5q21→q22. This region lies adjacent to a complex domain of growth factors and receptors, many involved in regulation of haematopoiesis. FER maps within a critical segment frequently deleted from chromosome 5 in patients with acute myeloid leukemia or myelodysplastic syndromes and was shown to be deleted in two such patients. It also maps close to the familial polyposis coli locus at 5q22.