Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity.
Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity.
复制标题
DOI：
10.1016/j.bbalip.2008.12.011
复制
发表时间：
2009-02
影响因子：
4.8
通讯作者：
Ntambi, James M.
中科院分区：
文献类型：
--
作者：
Flowers, Matthew I.;Ntambi, James M.
肥胖症目前是一种世界性流行病和公共卫生负担，其增加了发展胰岛素抵抗和几种慢性疾病如糖尿病、心血管疾病和非酒精性脂肪肝的风险。肥胖的多因素原因包括几个遗传，饮食和生活方式变量，共同导致能量摄入和能量消耗之间的不平衡。通常规定限制脂肪摄入的饮食方法以达到减肥所需的低热量条件。但是饮食脂肪限制通常伴随着碳水化合物摄入的增加，这可以显著增加内源性脂肪酸的合成，这取决于碳水化合物的组成。由于饮食和内源性合成的脂肪酸都对全身脂肪酸库有贡献，因此肥胖可能是由过量的脂肪或碳水化合物消耗引起的。硬脂酰辅酶A去饱和酶-1（SCD 1）是一种δ-9脂肪酸去饱和酶，可将饱和脂肪酸转化为单不饱和脂肪酸（MUFA），这种活性可通过膳食碳水化合物升高。缺乏Scd 1的小鼠可以免受肥胖和胰岛素抵抗的影响，其特征是脂肪酸合成减少和脂肪酸氧化增加。在这篇综述中，我们讨论了高碳水化合物饮食与SCD活性增加的关联，并总结了目前关于SCD 1和体重调节的文献。
Obesity is currently a worldwide epidemic and public health burden that increases the risk for developing insulin resistance and several chronic diseases such as diabetes, cardiovascular diseases and non-alcoholic fatty liver disease. The multifactorial causes of obesity include several genetic, dietary and lifestyle variables that together result in an imbalance between energy intake and energy expenditure. Dietary approaches to limit fat intake are commonly prescribed to achieve the hypocaloric conditions necessary for weight loss. But dietary fat restriction is often accompanied by increased carbohydrate intake, which can dramatically increase endogenous fatty acid synthesis depending upon carbohydrate composition. Since both dietary and endogenously synthesized fatty acids contribute to the whole-body fatty acid pool, obesity can therefore result from excessive fat or carbohydrate consumption. Stearoyl-Coenzyme A desaturase-1 (SCD1) is a delta-9 fatty acid desaturase that converts saturated fatty acids into monounsaturated fatty acids (MUFA) and this activity is elevated by dietary carbohydrate. Mice lacking Scd1 are protected from obesity and insulin resistance and are characterized by decreased fatty acid synthesis and increased fatty acid oxidation. In this review, we address the association of high-carbohydrate diets with increased SCD activity and summarize the current literature on the subject of SCD1 and body weight regulation.
登录
查看更多内容
影响因子：
64.5
作者：
Cao H;Gerhold K;Mayers JR;Wiest MM;Watkins SM;Hotamisligil GS
通讯作者：
Hotamisligil GS
影响因子：
6.5
作者：
Attie, AD;Krauss, RM;Ntambi, JM
通讯作者：
Ntambi, JM
影响因子：
15.9
作者：
Denechaud, Pierre-Damien;Bossard, Pascale;Postic, Catherine
通讯作者：
Postic, Catherine
影响因子：
7.1
作者：
BEHALL, KM;SCHOLFIELD, DJ;CANARY, J
通讯作者：
CANARY, J
影响因子：
7.1
作者：
Barclay, Alan W.;Petocz, Peter;Brand-Miller, Jennie C.
通讯作者：
Brand-Miller, Jennie C.