Anhedonia and substance-related symptoms in detoxified substance-dependent subjects: A correlation study
Anhedonia and substance-related symptoms in detoxified substance-dependent subjects: A correlation study
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DOI：
10.1159/000086176
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发表时间：
2005-01-01
影响因子：
3.2
通讯作者：
De Risio, S
中科院分区：
文献类型：
--
作者：
Janiri, L;Martinotti, G;De Risio, S
快感缺乏是一种体验快乐的能力完全或部分丧失的状况，经常发生在情绪障碍中，作为精神分裂症的阴性症状，以及物质使用障碍。为了测试一套仪器的快感缺乏在人口脱毒阿片类药物，酒精和多种物质依赖的主题，70人招募了来自三个不同的临床设置。应用以下量表：Snaith-Hamilton快乐量表（SHAPS）、Bech-Rafaelsen抑郁量表（BRMS）、阴性症状评估量表（SANS）、特定戒断量表和用于享乐能力和物质渴求的视觉模拟量表（VAS）。直接测量快感缺乏的量表（SHAPS、VAS）和某些关键项目（SANS、BRMS）之间存在显著相关。戒毒后的时间与快感缺乏和戒断症状呈负相关。渴求与快感缺乏呈正相关。在总样本中，只有18.5%可以被定义为心理测量学上的快感缺失。在这个子样本中发现了相同的相关性。用于评估快感缺乏和享乐能力的复合工具被认为是足够敏感的，以检测这样一个层面的人口考虑，与单尺度显着相关。总之，我们发现享乐能力，渴望和长期戒断之间的相互关系，特别是在阿片类药物依赖的主题。最强的关联发生在享乐能力和渴望之间。版权所有（C）2005 S. Karger AG，巴塞尔。
Anhedonia is a condition in which the capacity of experiencing pleasure is totally or partially lost, frequently occurring in mood disorders, as a negative symptom in schizophrenia, and in substance use disorders. In order to test a set of instruments for anhedonia in a population of detoxified opiate, alcohol and multiple substance-dependent subjects, 70 individuals were recruited from three different clinical settings. The following scales were applied: Snaith-Hamilton Pleasure Scale (SHAPS), Bech-Rafaelsen Melancholia Scale (BRMS), Scale for the Assessment of Negative Symptoms (SANS), specific withdrawal scales, and visual analogue scales (VAS) for hedonic capability and substance craving. The scales measuring anhedonia either directly (SHAPS, VAS for hedonic capability) or in some key items (SANS, BRMS) were significantly correlated with each other. The period of time since detoxification was inversely correlated with anhedonia and withdrawal symptomatology. Craving was positively correlated with anhedonia. Out of the total sample, only 18.5% could be defined as psychometrically anhedonic. The same correlations were found in this subsample. The composite instrument employed for assessing anhedonia and hedonic capability was found to be sensitive enough to detect such a dimension in the population considered, with the single scales significantly interrelated. In conclusion, we found interrelations between hedonic capability, craving and protracted withdrawal, particularly in opiate-dependent subjects. The strongest association occurred between hedonic capability and craving. Copyright (C) 2005 S. Karger AG, Basel.