Ni(II)-bis[(R,R)-N,N′-dibenzylcyclohexane-1,2-diamine]Br2 catalyzed enantioselective Michael additions of 1,3-dicarbonyl compounds to conjugated nitroalkenes
Ni(II)-bis[(R,R)-N,N′-dibenzylcyclohexane-1,2-diamine]Br2 catalyzed enantioselective Michael additions of 1,3-dicarbonyl compounds to conjugated nitroalkenes
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DOI：
10.1021/ja052935r
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发表时间：
2005-07-20
影响因子：
15
通讯作者：
Seidel, D
中科院分区：
文献类型：
--
作者：
Evans, DA;Seidel, D
采用新开发的Ni（II）−（bis）diamine基催化剂，开发了1，3-二羰基化合物与硝基烯烃的高对映选择性Michael加成反应。反应范围包括取代和未取代的丙二酸酯、β-酮酯和带有芳香族和脂肪族残基的硝基烯烃。该复合物的合成容易性是值得注意的。
A highly enantioselective Michael addition of 1,3-dicarbonyl compounds to nitroalkenes has been developed that employs a newly developed Ni(II)−(bis)diamine based catalyst. The reaction scope includes substituted and unsubstituted malonates, β-ketoesters, and nitroalkenes bearing aromatic and aliphatic residues. Ease of synthesis of this complex is noteworthy.