Respiratory muscle force and lung volume changes in a population of children with sickle cell disease.
Respiratory muscle force and lung volume changes in a population of children with sickle cell disease.
复制标题
镰状细胞病儿童群体的呼吸肌力和肺容量变化。
DOI：
10.1111/bjh.12481
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发表时间：
2013
影响因子：
6.5
通讯作者：
Allen,JulianL
中科院分区：
文献类型：
--
作者：
Ong,BruceA;Caboot,Jason;Jawad,Abbas;McDonough,Joseph;Jackson,Tannoa;Arens,Raanan;Marcus,CaroleL;Smith-Whitley,Kim;Mason,ThorntonBA;Ohene-Frempong,Kwaku;Allen,JulianL
镰状细胞病（SCD）是一种已知影响呼吸系统的疾病。我们试图在儿童SCD人群中确定呼吸肌力量和肺容量的关系。34名SCD - SS受试者进行了肺功能测试。身高、体重、年龄和性别调整百分比预测最大吸气压（MIP）和最大呼气压（MEP）值与肺活量测定和肺容量进行比较。统计学分析采用Pearson相关系数和配对双尾t检验。平均±标准差（SD） MIP和MEP分别为69·6±31.6 cm H2O和66·9±22·9 cm H2O，平均±SD %预测MIP（101·3±45·9）超过MEP(72·1±26·0)（P= 0.002）。MIP与用力肺活量（FVC;r= 0.51，P= 0.001）和TLC （r= 0.54，P< 0.0001）相关。MEP与FVC （r= 0.43，P= 0.011）、总肺活量（TLC;r= 0.42，P= 0.013）也有相关性。Pearson相关系数检验显示MIP与MEP之间存在相关性（r= 0.64，P< 0.0001）。SCD‐SS患者显示出呼吸肌力量和肺容量之间的相关性，与吸气肌力量相比，预测的呼气肌力量降低了百分之几。这些患者的呼吸肌力量可能影响肺容量，并且与膈肌相比，呼吸肌可能更容易受到SCD诱导的血管闭塞性损伤。
Sickle cell disease (SCD) is a disorder known to impact the respiratory system. We sought to identify respiratory muscle force and lung volume relationships in a paediatric SCD population. Thirty‐four SCD‐SS subjects underwent pulmonary function testing. Height, weight, age, and gender‐adjusted percent predicted maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) values were compared to spirometry and lung volumes. Statistical analyses were performed using Pearson's correlation coefficient and paired two‐tailed t‐test. The mean ± standard deviation (SD) MIP and MEP was 69·6 ± 31·6 cm H2O and 66·9 ± 22·9 cm H2O, respectively, and mean ± SD percent predicted MIP (101·3 ± 45·9) exceeded MEP (72·1 ± 26·0) (P= 0·002). MIP correlated with forced vital capacity (FVC;r= 0·51,P= 0·001) and TLC (r= 0·54,P< 0·0001). MEP also correlated with FVC (r= 0·43,P= 0·011) and total lung capacity (TLC;r= 0·42,P= 0·013). Pearson's correlation coefficient testing yielded relationships between MIP and MEP (r= 0·64,P< 0·0001). SCD‐SS patients showed correlations between respiratory muscle force and lung volume, and reduced percent predicted expiratory muscle force compared to inspiratory muscle force. Respiratory muscle strength may affect lung volumes in these patients, and expiratory muscles may be more susceptible than the diaphragm to SCD‐induced vaso‐occlusive damage.