Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction
Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction
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DOI：
10.1038/s41467-020-17257-7
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发表时间：
2020-07
影响因子：
16.6
通讯作者：
Lars-Lennart Oettl;M. Scheller;Carla Filosa;Sebastian Wieland;Franziska Haag;Cathrin Loeb;D. Durstewitz-D.
中科院分区：
文献类型：
--
作者：
Lars-Lennart Oettl;M. Scheller;Carla Filosa;Sebastian Wieland;Franziska Haag;Cathrin Loeb;D. Durstewitz-D.
对刺激-结果关联的学习使得对环境的预测成为可能。腹侧纹状体和多巴胺能中脑神经元形成一个更大的网络，从感觉线索产生奖励预测信号。然而，在这些分布式电路中产生预测信号的网络可塑性机制尚未完全阐明。此外，关于潜在的区域间聚集形成和信息传递的直接证据仍然缺乏。在这里，我们表明，即使在没有奖励的情况下，阶段性多巴胺也足以加强腹侧纹状体刺激表征的独特性。在这种强化下，纹状体刺激编码产生区域间组装，在刺激-结果学习过程中驱动多巴胺能神经元。这些组合动态地编码条件刺激的预期奖励值。总之，我们的数据显示腹侧纹状体和中脑奖励网络形成了一个强化循环来产生奖励预测编码。
The learning of stimulus-outcome associations allows for predictions about the environment. Ventral striatum and dopaminergic midbrain neurons form a larger network for generating reward prediction signals from sensory cues. Yet, the network plasticity mechanisms to generate predictive signals in these distributed circuits have not been entirely clarified. Also, direct evidence of the underlying interregional assembly formation and information transfer is still missing. Here we show that phasic dopamine is sufficient to reinforce the distinctness of stimulus representations in the ventral striatum even in the absence of reward. Upon such reinforcement, striatal stimulus encoding gives rise to interregional assemblies that drive dopaminergic neurons during stimulus-outcome learning. These assemblies dynamically encode the predicted reward value of conditioned stimuli. Together, our data reveal that ventral striatal and midbrain reward networks form a reinforcing loop to generate reward prediction coding.