Susceptibility of Schistosoma japonicum to praziquantel in China
Susceptibility of Schistosoma japonicum to praziquantel in China
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DOI：
10.1046/j.1365-3156.2001.00772.x
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发表时间：
2001-09-01
影响因子：
3.3
通讯作者：
Coles, GC
中科院分区：
文献类型：
--
作者：
Liang, YS;Dai, JR;Coles, GC
为了寻找日本血吸虫对吡喹酮产生抗药性的可能证据，我们在中国进行了现场研究。在血吸虫病非传播期，随机抽取中国3省6个村2860人，进行粪便寄生虫学检查。在372名粪便呈阳性的受试者中，363名受试者接受了单剂量40毫克/公斤的吡喹酮治疗。治疗后6~7周，对334例患者进行相同的粪便检查，319例患者的粪便检测结果为阴性，寄生虫学治愈率为95.5%。15名仍在排卵的受试者接受了相同剂量的吡喹酮第二次治疗。所有的粪便样本，包括再次接受吡喹酮治疗的参与者的粪便样本，在第一次治疗12周后进行了重新检查，没有发现粪便阳性受试者。结果表明，尽管在中国主要流行区广泛使用吡喹酮10多年，但仍未发现降低日本血吸虫对吡喹酮敏感性的证据。与曼氏血吸虫比较，日本血吸虫尾蚴、毛虫和虫卵对吡喹酮的体外反应表明，日本血吸虫尾蚴、毛虫和虫卵对吡喹酮的反应较弱。日本血吸虫卵对吡喹酮的敏感性高于曼氏血吸虫。更敏感的蠕虫不太可能产生抗药性，这可以解释为什么在中国的日本血吸虫中没有发现抗药性的证据。
To look for possible evidence of the development of resistance in Schistosoma japonicum to praziquantel, we conducted a field study in China. During the non-transmission period of schistosomiasis a random sample of 2860 individuals from six villages in three provinces of China were examined using a parasitological stool examination. Of the 372 stool-positive subjects, 363 subjects were treated with a single oral dose of 40 mg/kg of praziquantel. Six to Seven weeks after treatment, of 334 subjects examined using the same stool examination, stool-negative results were found in 319 patients which represents a 95.5% parasitologic cure rate. Fifteen subjects still excreting eggs were treated a second time with the same dose of praziquantel. All stool samples, including those from participants re-treated with praziquantel, were re-examined 12 weeks after the first treatment and no stool-positive subjects were found. The results indicate that there was no evidence for reduced susceptibility of S. japonicum to praziquantel despite its extensive use in the main endemic areas of China for more than 10 years. The in vitro responses to praziquantel of cercariae, miracidia and eggs of S. japonicum compared with S. mansoni demonstrate that the cercariae, miracidia. and eggs of S. japonicum are more sensitive to praziquantel than those of S. mansoni. More sensitive worms would be less likely to develop resistance and this could explain why no evidence for resistance was found in S. japonicum in China.