Characterization of Bone Structure in Leptin Receptor‐Deficient Zucker (fa/fa) Rats
Characterization of Bone Structure in Leptin Receptor‐Deficient Zucker (fa/fa) Rats
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DOI:
10.1359/jbmr.2003.18.9.1605
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发表时间:
2003-09
影响因子:
6.2
通讯作者:
J. Tamasi;B. Arey;D. Bertolini;J. Feyen
中科院分区:
文献类型:
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作者:
J. Tamasi;B. Arey;D. Bertolini;J. Feyen
To investigate the role of leptin in bone formation, the skeleton of the obese female leptin receptor‐deficient Zucker rat was examined using pQCT, μCT, and histomorphometry. A trend toward decreasing structural and bone formation parameters in these rats as they age suggest that leptin has a small positive effect on bone.