Characterization of Bone Structure in Leptin Receptor‐Deficient Zucker (fa/fa) Rats

Characterization of Bone Structure in Leptin Receptor‐Deficient Zucker (fa/fa) Rats
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DOI:
10.1359/jbmr.2003.18.9.1605
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发表时间:
2003-09
影响因子:
6.2
通讯作者:
J. Tamasi;B. Arey;D. Bertolini;J. Feyen
J. Tamasi;B. Arey;D. Bertolini;J. Feyen
中科院分区:
医学1区
文献类型:
--
作者:
J. Tamasi;B. Arey;D. Bertolini;J. Feyen

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为了研究瘦素在骨形成中的作用,使用pQCT、μCT和组织形态计量学检查肥胖雌性瘦素受体缺陷Zucker大鼠的骨骼。随着年龄的增长,这些大鼠的结构和骨形成参数呈下降趋势,表明瘦素对骨有小的积极影响。
To investigate the role of leptin in bone formation, the skeleton of the obese female leptin receptor‐deficient Zucker rat was examined using pQCT, μCT, and histomorphometry. A trend toward decreasing structural and bone formation parameters in these rats as they age suggest that leptin has a small positive effect on bone.